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The destruction of blood–brain barrier (BBB) and blood-nerve barrier (BNB) has been considered to be a key step in the disease process of a number of neurological disorders including cerebral ischemia, Alzheimer’s disease, multiple sclerosis, and diabetic neuropathy. Although glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic(More)
Since the diversification of the electromagnetic (EM) environment is spreading, it is essential to estimate the EM energy absorption rate [specific absorption rate (SAR)] of a pregnant woman's body and her fetus under various exposure situations. This paper presents the EM dosimetry in a pregnant woman in proximity to a mobile-phone terminal using the(More)
Oral bisphosphonates (BPs) represent the first line of prevention and treatment for osteoporosis. However, several studies have reported osteonecrosis of the jaw (ONJ), also known as osteomyelitis of the jaw (OMJ), as a side effect of these drugs. Although absolute risk is suggested to be low, information to date on the relative risk or attributable risk(More)
In recent years, various types of applications of electromagnetic techniques to microwave thermal therapies have been developed. The authors have been studying the coaxial-slot antenna, which is one of the thin microwave antennas, for the minimally invasive microwave thermal therapies, such as interstitial microwave hyperthermia. From the results of our(More)
The changes in the quality of Japanese clinical trials were evaluated by comparing the results of Good Clinical Practice (GCP) audits conducted from April 1997 to March 2000 (fiscal year (FY) 1997-1999) with those from April 2001 to March 2002 (FY2001). During both of the periods inspections were undertaken by the Organization for Pharmaceutical Safety and(More)
We review the techniques and outcomes of the intragastric resection for gastric submucosal tumors (GSTs) using laparoscope and oral endoscope. In the literature, the mean operation time, intraoperative blood loss, pathological size of the tumor and postoperative hospital stay were 134 min, minimal, 31 mm and 6.4 d, respectively. There were no particular(More)
To describe qualitatively recent changes in the Japanese clinical trial environments, we compared the results of the Good Clinical Practice (GCP) audits conducted from April 1997 to March 2000 (FY1997 to FY1999) with those from April 2002 to March 2003 (FY2002). In addition, the audit results were compared between the United States and Japan. The audit(More)
BACKGROUND Japanese clinical trials have some unique characteristics in both design and conduct. We have studied recent changes in quality in Japanese clinical trials. OBJECTIVE To describe quantitatively recent drastic changes in Japanese clinical trial environments by comparing the results of Good Clinical Practice (GCP) audits conducted from April 1997(More)
Magnetic resonance imaging (MRI) is a noninvasive imaging techniques used to visualize the inside of the human body based on nuclear magnetic resonance. Currently, RF coils that transmit high frequency and high power of electromagnetic (EM) wave pulses are being investigated to obtain high-quality images and to shorten the imaging time. Due to these(More)
Preindustrial changes in the Asian summer monsoon climate from the 1700s to the 1850s were estimated with an atmospheric general circulation model (AGCM) using historical global land cover/use change data reconstructed for the last 300 years. Extended cultivation resulted in a decrease in monsoon rainfall over the Indian subcontinent and southeastern China(More)