Kazuyuki Ishihara

Eitoyo Kokubu3
Takayuki Endoh2
Masakazu Tazaki2
Sadamitsu Hashimoto2
3Eitoyo Kokubu
2Takayuki Endoh
2Masakazu Tazaki
2Sadamitsu Hashimoto
Learn More
  • Satosu Onozawa, Yuichiro Kikuchi, Kazuko Shibayama, Eitoyo Kokubu, Masaaki Nakayama, Tetsuyoshi Inoue +7 others
  • 2015
BACKGROUND Porphyromonas gingivalis has been implicated as a major pathogen in the development and progression of chronic periodontitis. P. gingivalis biofilm formation in the subgingival crevice plays an important role in the ability of the bacteria to tolerate stress signals outside the cytoplasmic membrane. Some bacteria use a distinct subfamily of sigma(More)
  • Min Ao, Mutsumi Miyauchi, Toshihiro Inubushi, Masae Kitagawa, Hisako Furusho, Toshinori Ando +7 others
  • 2014
BACKGROUND A number of studies have revealed a link between chronic periodontitis and cardiovascular disease in obese patients. However, there is little information about the influence of periodontitis-associated bacteria, Porphyromonas gingivalis (Pg), on pathogenesis of atherosclerosis in obesity. METHODS In vivo experiment: C57BL/6J mice were fed with(More)
BACKGROUND Smoking is a risk factor for periodontitis. To clarify the contribution of smoking to periodontitis, it is essential to assess the relationship between smoking and the subgingival microflora. The aim of this study was to gain an insight into the influence of smoking on the microflora of Japanese patients with periodontitis. METHODS Sixty-seven(More)
Galanin (GAL), a 29-amino-acid neuropeptide, is involved in various neuronal functions, including the regulation of food intake, hormone secretion and central cardiovascular regulation. The nucleus tractus solitarius (NTS) is known to plays a major role in the regulation of cardiovascular, respiratory, gustatory, hepatic and swallowing functions.(More)
  • Makoto Hagiwara, Eitoyo Kokubu, Shinsuke Sugiura, Toshinori Komatsu, Hiroyuki Tada, Ryutaro Isoda +7 others
  • 2014
Vinculin, a 116-kDa membrane cytoskeletal protein, is an important molecule for cell adhesion; however, little is known about its other cellular functions. Here, we demonstrated that vinculin binds to Rab5 and is required for Staphylococcus aureus (S. aureus) uptake in cells. Viunculin directly bound to Rab5 and enhanced the activation of S. aureus uptake.(More)
  • Kimiko Tanaka-Kumazawa, Yuichiro Kikuchi, Yumiko Sano-Kokubun, Seikou Shintani, Masashi Yakushiji, Howard K. Kuramitsu +1 other
  • 2016
BACKGROUND Treponema denticola is strongly associated with the development of periodontal disease. Both synergistic and antagonistic effects are observed among bacterial species in the process of biofilm formation. Bacteriocin-related genes have not yet been fully characterized in periodontopathic bacteria. The aim of this study was to detect and(More)
  • Kyoko Hosohama-Saito, Eitoyo Kokubu, Kazuko Okamoto-Shibayama, Daichi Kita, Akira Katakura, Kazuyuki Ishihara +1 other
  • 2016
Capnocytophaga ochracea is present in the dental plaque biofilm of patients with periodontitis. Biofilm cells change their phenotype through quorum sensing in response to fluctuations in cell-population density. Quorum sensing is mediated by auto-inducers (AIs). AI-2 is involved in intercellular signaling, and production of its distant precursor is(More)
This paper describes the asset management system (AMS) that enables sharing, manipulation and version management of various digital data in production workflow at OLM Digital. In the past, our digital asset has been managed by each film work manager. Each manager uses his own file and directory naming convention. Unfortunately, these rules were sometimes(More)
OBJECTIVE Neurotrophins, such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), promote neuronal development and neuronal survival, but their mechanisms remain controversial. This study aimed to investigate the hypothesis that NGF and BDNF interfere with angiotensin-II- and glutamate-induced facilitation of voltage-dependent Ca(2+)(More)
  • 1