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The small bristles (microchaetes) on the thorax of adult Drosophila are evenly spaced. We have analysed the development of this pattern using the enhancer trap line A101 where bacterial lacZ is expressed in the microchaete sensory mother cells (SMCs) and their progeny. We observed that the precursor cells appear in a stereotyped pattern of rows. Within each(More)
BACKGROUND Genes of the achaete-scute complex encode transcription factors whose activity regulates the development of neural cells. The spatially restricted expression of achaete-scute on the mesonotum of higher flies governs the development and positioning of the large sensory bristles. On the scutum the bristles are arranged into conserved patterns,(More)
Overactivation of poly(ADP-ribose) polymerase-1 (PARP-1) has been demonstrated to result in various stress-related diseases, including diabetes mellitus. Deficiency of cellular nicotinamide adenine dinucleotide (NAD(+)) content, consumed by PARP-1 to add ADP-ribose moieties onto target proteins, contributes to pathophysiological conditions. Adenosine(More)
 The tactile bristles of the fly comprise four cells that originate from a single precursor cell through a fixed lineage. The gene tramtrack (ttk) plays a crucial role in defining the fates of these cells. Here we analyse the normal pattern of expression of ttk, as well as the effect of ttk overexpression at different steps of the lineage. We show that ttk(More)
The pattern of sense organs is often remarkably constant in arthropods. How such a precise and reproducible pattern is generated has been extensively studied in the case of the mechanosensory bristles on the notum of Drosophila. Three types of innervated bristles are present on the notum of the adult: large bristles (macrochaetes), small bristles(More)
The notum of Drosophila is a good model system for the study of two-dimensional pattern formation. Attention has mainly focused on the regulation of the spatial expression of the genes of the achaete-scute complex (AS-C) that results in a stereotyped bristle pattern. Expression of AS-C genes has traditionally been viewed as a consequence of the activity of(More)
We previously found that thiamine mitigates metabolic disorders in spontaneously hypertensive rats, harboring defects in glucose and fatty acid metabolism. Mutation of thiamine transporter gene SLC19A2 is linked to type 2 diabetes mellitus. The current study extends our hypothesis that thiamine intervention may impact metabolic abnormalities in Otsuka(More)
 In Drosophila, the sensory mother cells of macrochaetes are chosen from among the mitotically quiescent clusters of cells in wing imaginal discs, where other cells are proliferating. The pattern of cyclin A, one of the G2 cyclins, reveals that mitotically quiescent clusters of cells are arrested in G2. When precocious mitoses are induced during sensory(More)
With recent popularity of 3D models, retrieval and recognition of 3D models based on their shape has become an important subject of study. This paper proposes a 3D model retrieval algorithm that is invariant to global deformation as well as to similarity transformation of 3D models. The algorithm is based on a set of local 3D geometrical features combined(More)
The thoracic bristle pattern of Drosophila results from the spatially restricted expression of the achaete-scute (ac-sc) genes in clusters of cells, mediated by the activity of many discrete cis-regulatory sequences. However, ubiquitous expression of sc or asense (ase) achieved with a heterologous promoter, in the absence of endogenous ac-sc expression, and(More)