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A 60-year-old man received interferon/ribavirin combination therapy for chronic hepatitis C in 2002 and achieved sustained virological response. In 2008, a hepatocellular carcinoma (HCC) with a diameter of 60 mm appeared and surgical resection was performed. In March 2011, the patient was referred to our hospital because of portal lymph node swelling.(More)
Liver consists of parenchymal hepatocytes and other cells. Liver progenitor cell (LPC) is the origin of both hepatocytes and cholangiocytic cells. The analyses of mechanism regulating differentiation of LPCs into these functional cells are important for liver regenerative therapy using progenitor cells. LPCs in adult livers were found to form cysts with(More)
BACKGROUND Off-treatment durability of nucleoside analogue (NA) therapy in patients with chronic hepatitis B has not been well investigated. In this study we monitored antiviral effect of NA therapy and evaluated off-treatment durability after NA cessation in patients with chronic hepatitis B. PATIENTS AND METHODS A total of 94 consecutive patients (39(More)
1 T he indocyanine green (ICG) retention test is widely used for preoperative evaluation of liver function. Individuals who have markedly poor ICG clearance without severe liver diseases are defined as patients with a " constitutional ICG excretory defect. " (1) However, the underlying molecular mechanisms remain unknown. We hypothesized that the ICG(More)
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