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- Kazutoshi Takahashi, Shinya Yamanaka
- Cell
- 2006
Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce… (More)
- Kazutoshi Takahashi, Koji Tanabe, +4 authors Shinya Yamanaka
- Cell
- 2007
Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced… (More)
- Kaoru Mitsui, Yoshimi Tokuzawa, +6 authors Shinya Yamanaka
- Cell
- 2003
Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts grow infinitely while maintaining pluripotency. Leukemia inhibitory factor (LIF) can maintain self-renewal of mouse ES… (More)
- Masato Nakagawa, Michiyo Koyanagi, +7 authors Shinya Yamanaka
- Nature Biotechnology
- 2008
Direct reprogramming of somatic cells provides an opportunity to generate patient- or disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were generated from mouse… (More)
- Shinya Yamanaka, Kazutoshi Takahashi
- Tanpakushitsu kakusan koso. Protein, nucleic acid…
- 2006
- Hyenjong Hong, Kazutoshi Takahashi, +5 authors Shinya Yamanaka
- Nature
- 2009
Induced pluripotent stem (iPS) cells can be generated from somatic cells by the introduction of Oct3/4 (also known as Pou5f1), Sox2, Klf4 and c-Myc, in mouse and in human. The efficiency of this… (More)
- Kazutoshi Takahashi, Keisuke Okita, Masato Nakagawa, Shinya Yamanaka
- Nature Protocols
- 2007
Clinical application of embryonic stem (ES) cells faces difficulties regarding use of embryos, as well as tissue rejection after implantation. One way to circumvent these issues is to generate… (More)
- Takayuki Kondo, Masashi Asai, +40 authors Haruhisa Inoue
- Cell stem cell
- 2013
Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we generated induced… (More)
- Yasuhiko Hirami, Fumitaka Osakada, +5 authors Masayo Takahashi
- Neuroscience letters
- 2009
We previously reported a technique for generating retinal pigment epithelia (RPE) and putative photoreceptors from embryonic stem (ES) cells. Here we tested whether our procedure can promote retinal… (More)
- Kazutoshi Takahashi, Kaoru Mitsui, Shinya Yamanaka
- Nature
- 2003
Embryonic stem (ES) cells are pluripotent cells derived from early mammalian embryos. Their immortality and rapid growth make them attractive sources for stem cell therapies; however, they produce… (More)