Kazutoshi Takahashi

Publications146
h-index48
Citations55,236
Highly Influential Citations2,272
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Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
TLDR
Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Expand
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
TLDR
It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc. Expand
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
TLDR
Nanog is a critical factor underlying pluripotency in both ICM and ES cells, and it is found that one of them, encoding the homeoprotein Nanog, was capable of maintaining ES cell self-renewal independently of LIF/Stat3. Expand
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
TLDR
A modified protocol for the generation of iPS cells that does not require the Myc retrovirus is described and, with this protocol, significantly fewer non-iPS background cells are obtained, and theiPS cells generated were consistently of high quality. Expand
Induction of Pluripotent Stem Cells From Adult Human Fibroblasts by Defined Factors
TLDR
This work generated induced pluripotent stem cells capable of germline transmission from murine somatic cells by transd, and demonstrated the ability of these cells to reprogram into patient-specific and disease-specific stem cells. Expand
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
TLDR
Functional analyses of 34 p53-regulated genes demonstrate that the p53–p21 pathway serves as a barrier not only in tumorigenicity, but also in iPS cell generation in mouse and human fibroblasts. Expand
Induction of pluripotent stem cells from fibroblast cultures
TLDR
Detailed methods and tips for the generation of induced pluripotent stem cells, named iPS cells, can be differentiated into three germ layers and committed to chimeric mice are described. Expand
Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells
TLDR
The new work provides an encouraging step toward using motor neurons generated from iPSCs derived from ALS patients to learn more about what triggers the death of motor neurons in this disease and to identify new candidate drugs that may be able to slow or reverse the devastating loss ofMotor neurons. Expand
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
TLDR
Genetic lineage tracings suggest that iPS cells are generated by direct reprogramming of lineage-committed somatic cells and that retroviral integration into specific sites is not required. Expand
Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
TLDR
It is shown that human induced pluripotent stem cells differentiate into incipient mesoderm-like cells (iMeLCs), which robustly generate human primordial germ cell- like cells (hPGCLCs) that can be purified using the surface markers EpCAM and INTEGRINα6. Expand
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