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Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. Taxonomy, fermentation, isolation and physico-chemical characterization.
Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp. NR0516. It was isolated from fermentation broth by extraction with butyl alcohol, QAE-Toyopearl column chromatography andExpand
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A new antibiotic, fumaramidmycin. II. Isolation, structure and syntheses.
A new antibiotic fumaramidmycin produced by Streptomyces kurssanovii NR-7GG1 was isolated as colorless crystals. The structure was shown to be N-(phenylacetyl) fumaramide. Starting from fumaramicExpand
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Interaction of ribosome recycling factor and elongation factor EF‐G with E. coli ribosomes studied by the surface plasmon resonance technique
Ribosome recycling factor (RRF), in concert with elongation factor EF‐G, is required for disassembly of the post‐termination complex of a ribosome after the release of polypeptides. How RRFExpand
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Structure of cyclothiazomycin, a unique polythiazole-containing peptide with renin inhibitory activity. Part 1. Chemistry and partial structures of cyclothiazomycin
Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp.NR0516 (IC50 1.66μM). Its molecular formula was determined to be C59H64H18O14S7 (MW .1472) based on high-resolution FAB massExpand
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Structure of cyclothiazomycin, a unique polythiazole-containing peptide with renin inhibitory activity. Part 2. Total structure
Abstract Structure of cyclothiazomycin, a novel renin inhibitor isolated from cultured broth of Streptomyces sp . NR0516, was determined to be a unique polythiazole-containing peptide related toExpand
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New alpha-amylase inhibitor, trestatins. II. Structure determination of trestatins A, B and C.
The structures of trestatins A (C56H94N2O40), B (C37H63NO28) and C (C75H125N3O52), new basic oligosaccharides with potent inhibitory activity against various alpha-amylases, have been shown byExpand
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[Cholecystokinin receptor antagonists].
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Tetronothiodin, a novel cholecystokinin type-B receptor antagonist produced by Streptomyces sp.
Tetronothiodin (1) is a potent and selective cholecystokinin type B (CCK-B) receptor antagonist produced by Streptomyces sp. NR0489. Its structure was elucidated to be a macrocyclic compoundExpand
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Comparative Antitumor Activity and Intestinal Toxicity of 5′‐Deoxy‐5‐fluorouridine and Its Prodrug Trimethoxybenzoyl‐5′‐deoxy‐5‐fluorocytidine
N4‐Trimethoxybenzoyl‐5′‐deoxy‐5‐fluorocytidine (Ro 09–1390), a prodrug of the cytostatic 5′‐deoxy‐5‐fluorouridine (5′‐DFUR), was synthesized with the aim of reducing of the dose‐limiting toxicity ofExpand
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