Kazushige Moriyama

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Measurements of serum concentrations of Des-gamma-carboxy Prothrombin (PIVKA-II) are widely used for diagnosing hepatocellular carcinoma (HCC). Recently, in Lumipulsef assay, it was reported that antibodies against alkaline phosphatase (ALP) derived from anti bleeding sheets led false high values of PIVKA-II in the patients with HCC resection. To improve(More)
HBsAg is an envelope surface protein of the hepatitis B virus, and a marker of hepatitis B infection. In Japan, an HBsAg reagent was adopted as a blood screening test by the Japan Red Cross in 1972. Furthermore, a highly sensitive HBsAg reagent has been in use since 2008. Blood screening with HBsAg reagent use has contributed to a decrease in hepatitis B(More)
Immunoassay using antibodies is widely applied to measure various clinical parameters such as tumor markers. However, many mechanisms of interference for this method have been reported. We studied serum sample showing false positive CA19-9 values in the range of 24 to approximately 286U/ml depending on the reagent lots used. PEG-pretreated serum did not(More)
Hepatitis B surface antigen (HBsAg) is used as a clinical marker of hepatitis B virus (HBV) infection. However, conventional HBsAg assays have so far failed to accurately detect HBsAg in blood because of interference by patient-derived antibodies against HBsAg (HBsAb). We developed a novel, fully automated assay system that can detect total HBsAg in blood,(More)
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