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Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines
Results indicate that both neuronal-type Nc and Ms ACh receptors are present on the surface of lymphocytes, to investigate whether ACh in the blood acts on lymphocytes and participates in the modulation of immune responses. Expand
Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines
The results suggest that the major portion of ACh in the circulating blood originates from T-lymphocytes, which is localized in circulating mononuclear leukocytes in humans. Expand
l-DOPA inhibits spontaneous acetylcholine release from the striatum of experimental Parkinson's model rats
Findings suggest that L-DOPA-sensitive mechanisms are supersensitized in Parkinson's disease model rats. Expand
Expression of glycine receptor subunits in the cochlear nucleus and superior olivary complex using non-radioactive in-situ hybridization
Results indicate that GlyR is being expressed all major CN and SOC neurons, with alpha 1-, alpha 3- and beta-subunit components of the mature receptor and the alpha 2-sub unit, a component of the immature GlyR, which is not down-regulated until after 6 weeks of age in most CN andOC neurons. Expand
6-OHDA-induced lesion of the nigrostriatal dopaminergic neurons potentiates the inhibitory effect of 7-OHDPAT, a selective D3 agonist, on acetylcholine release during striatal microdialysis in
There may exist intrastriatal D3 receptors to inhibit ACh release, and supersensitization is evident in a 6-OHDA-lesioned rat Parkinson's model. Expand
Mapping of the cochlear nucleus subregions in the rat with neuronal Fos protein induced by acoustic stimulation with low tones
To explore the mode of appearance of Fos, a gene product of proto-oncogene c-fos, in the cochlear nucleus, a pure tone was given to rats and Fos was detected by immunohistochemistry. FollowingExpand
Diversity and plasticity in amino acid receptor subunits in the rat auditory brain stem
The diversity that has been found in the subunit composition of GABA, glycine, alpha amino-3-hydroxy-5-methyl-4 isoxazole propionic acid and N-Methyl, D-aspartate (NMDA) receptors in the mammalian auditory brain stem is reviewed and new data on how the NMDAR1 glutamate receptor subunit changes as a consequence of deafness is provided. Expand
Supersensitization of intrastriatal dopamine receptors involved in opposite regulation of acetylcholine release in Parkinson's model rats
Evidence is demonstrated for the existence of intrastriatal D1 and D2 receptors regulating ACh release and for supersensitization of the striatal stimulatory D 1 and inhibitory D2 receptor mechanisms in 6-OHDA lesioned rats. Expand
Changes in cochlear electrical stimulation induced Fos expression in the rat inferior colliculus following deafness
Observations indicate that both deafness and chronic electrical stimulation may alter central auditory processing in rats evoked by basal or apical monopolar cochlear electrical stimulation. Expand
Expression of glycine receptor subunit mRNAs in the rat cochlear nucleus
The distribution of glycine receptor subunit mRNAs in the cochlear nucleus of the adult rat was examined using radioactive in situ hybridization to predict differences in glycinergic pharmacological properties between the co chlear nucleus neurons. Expand