DNA Methylation Status of SOX10 Correlates with Its Downregulation and Oligodendrocyte Dysfunction in Schizophrenia
- K. Iwamoto, M. Bundo, Tadafumi Kato
- Medicine, BiologyJournal of Neuroscience
- 1 June 2005
It is found that the cytosine-guanine dinucleotide (CpG) island of sex-determining region Y-box containing gene 10 (SOX10), an oligodendrocyte-specific transcription factor, tended to be highly methylated in brains of patients with schizophrenia, correlated with reduced expression of SOX10.
Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia
- Kazuo Yamada, D. Gerber, T. Yoshikawa
- Psychology, MedicineProceedings of the National Academy of Sciences
- 20 February 2007
The previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis is supported and EGR3 is identified as a compelling susceptibility gene.
Genome-Wide Association Study of Schizophrenia in Japanese Population
- Kazuo Yamada, Y. Iwayama, T. Yoshikawa
- Psychology, MedicinePLoS ONE
- 6 June 2011
A three-stage analysis of three independent cohorts consisting of a total of 2,535 samples from Japanese and Chinese populations for searching schizophrenia susceptibility genes using a GWAS approach finds the current data in Asian population would be helpful for deciphering ethnic diversity of schizophrenia etiology.
Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals
- M. Arai, M. Itokawa, T. Yoshikawa
- BiologyBiological Psychiatry
- 15 April 2004
Genetic analyses of Roundabout (ROBO) axon guidance receptors in autism
- A. Anitha, Kazuhiko Nakamura, N. Mori
- BiologyAmerican Journal of Medical Genetics Part B…
- 5 October 2008
It is suggested that abnormalities of ROBO may lead to autism either by interfering with serotonergic system, or by disrupting neurodevelopment, in the pathogenesis of autism.
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls
- T. Munesue, S. Yokoyama, H. Higashida
- BiologyNeurosciences research
- 1 June 2010
Association Between Polymorphisms in the Promoter Region of the Sialyltransferase 8B (SIAT8B) Gene and Schizophrenia
- M. Arai, Kazuo Yamada, M. Itokawa
- Medicine, PsychologyBiological Psychiatry
- 1 April 2006
Identification of Multiple Serine Racemase (SRR) mRNA Isoforms and Genetic Analyses of SRR and DAO in Schizophrenia and d-Serine Levels
- Kazuo Yamada, T. Ohnishi, T. Yoshikawa
- Medicine, PsychologyBiological Psychiatry
- 15 June 2005
Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder.
- K. Munakata, Masashi Tanaka, Tadafumi Kato
- BiologyGenomics
- 1 December 2004
...
...