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Direct Metagenomic Detection of Viral Pathogens in Nasal and Fecal Specimens Using an Unbiased High-Throughput Sequencing Approach
The results suggest that the unbiased high-throughput sequencing approach is useful for directly detecting pathogenic viruses without advance genetic information, and could be useful for the earlier discovery of novel emerging viruses and bioterrorism, which are difficult to detect with conventional procedures. Expand
Accumulation of Bisphenol A in Hemodialysis Patients
Among renal disease patients who had not undergone hemodialysis, the serum BPA concentration increased as the renal function deteriorated, showing a significant negative association with BPA. Expand
Serum under-galactosylated IgA1 is increased in Japanese patients with IgA nephropathy.
HAA-IgA binding is significantly increased in Japanese IgAN patients and the O-glycan structure of IgA1 hinge glycopeptides was shifted to smaller molecular weights in high HAA- IgA-binding IgAN Patients. Expand
Analysis of IgA1 N-glycosylation and its contribution to FcalphaRI binding.
Kinetic and equilibrium data from surface plasmon resonance experiments revealed that variation in the IgA1 C H2 N-glycans had no effect on the kinetics or affinity constants for binding to FcalphaRI, which has implications for renal diseases such as IgA nephropathy. Expand
Clustered O-Glycans of IgA1
The results represent a new clinically relevant approach that requires ECD/electron transfer dissociation-type fragmentation to define the molecular events leading to pathogenesis of a chronic kidney disease and offers generally applicable principles for the analysis of clustered sites of O-glycosylation. Expand
Structural analyses of O-glycan sugar chains on IgA1 hinge region using SELDI-TOFMS with various lectins.
A lectin-immobilized ProteinChip assay can be used to simplify the procedures for the analyses of the O-glycans in IgA1 hinge, and potentially makes it possible to identify a disease-specific glycoform by selecting the appropriate ligand-coupled ProteinChip array. Expand
Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients with Chronic Kidney Disease
Elevated plasma NGAL could predict future CV events in CKD patients with no history of CV events and add incremental value to the established risk model. Expand
Naturally occurring structural isomers in serum IgA1 o-glycosylation.
The identification and elucidation of IgA1 O-glycopeptide structural isomers that occur based on amino acid position of the attached glycans and the structure of the O- glycan chains at individual sites (glycan isomers) are reported. Expand
In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy.
Immunoglobulin A nephropathy (IgAN) is a worldwide disease characterized by the presence of galactose-deficient IgA1 deposits in the glomerular mesangium. A kidney biopsy for diagnosis is required.Expand
Comparison of effective impact among tonsillectomy alone, tonsillectomy combined with oral steroid and with steroid pulse therapy on long-term outcome of immunoglobulin A nephropathy
A combination therapy of tonsillectomy and steroid pulse had the most significant therapeutic impact compared to other therapies. Expand