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Practical scheduling problems generally require allocation of resources in the presence of a large, diverse and typically connicting set of constraints and optimization criteria. The ill-structuredness of both the solution space and the desired objectives make scheduling problems diicult to formalize. This paper describes a case-based learning method for(More)
The present study describes the seasonal changes in lipid components of two brown algae, Sargassum horneri (Turner) and Cystoseira hakodatensis (Yendo), with specific reference to fucoxanthin (Fx) and n-3 (omega-3) polyunsaturated fatty acids (PUFAs). Young thalli of S. horneri were collected from different places, Nesaki and Matsushima, and cultivated in(More)
Mitochondrial uncoupling protein 1 (UCP1) is usually expressed only in brown adipose tissue (BAT) and a key molecule for metabolic thermogenesis to avoid an excess of fat accumulation. However, there is little BAT in adult humans. Therefore, UCP1 expression in tissues other than BAT is expected to reduce abdominal fat. Here, we show reduction of abdominal(More)
1 We have developed an approach to acquire complicated user optimization criteria and use them to guide iterative solution improvement. The effectiveness of the approach was tested on job shop scheduling problems. The ill-structuredness of the domain and the desired optimization objectives in real-life problems, such as factory scheduling, makes the(More)
Fucoxanthin has a unique structure including an unusual allenic bond and 5, 6-monoepoxide in its molecule. We found that abdominal white adipose tissue (WAT) weights of rats and mice fed fucoxanthin were significantly lower than those fed a control diet. The daily intake of fucoxanthin in mice also caused a significant reductions of body weight. Clear(More)
This study compared the growth inhibitory effects of pure conjugated linoleic acid (CLA) isomers [cis(c)9,c11-CLA, c9,trans(t)11-CLA, t9,t11-CLA, and t10,c12-CLA] on human colon cancer cell lines (Caco-2, HT-29 and DLD-1). When Caco-2 cells were incubated up to 72 h with 200 microM, each isomer, even in the presence of 10% fetal bovine serum (FBS), cell(More)
Adding knowledge to a knowledge-based system is not monotonically beneecial. We discuss and experimentally validate this observation in the context of CABINS, a system that learns control knowledge for iterative repair in ill-structured optimization problems. In CABINS , situation-dependent user's decisions that guide the repair process are captured in(More)
Fucoxanthin (Fx) isolated from Undaria pinnatifida suppresses the development of hyperglycemia and hyperinsulinemia of diabetic/obese KK-A(y) mice after 2 weeks of feeding 0.2% Fx-containing diet. In the soleus muscle of KK-A(y) mice that were fed Fx, glucose transporter 4 (GLUT4) translocation to plasma membranes from cytosol was promoted. On the other(More)