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Practical scheduling problems generally require allocation of resources in the presence of a large, diverse and typically connicting set of constraints and optimization criteria. The ill-structuredness of both the solution space and the desired objectives make scheduling problems diicult to formalize. This paper describes a case-based learning method for(More)
Mitochondrial uncoupling protein 1 (UCP1) is usually expressed only in brown adipose tissue (BAT) and a key molecule for metabolic thermogenesis to avoid an excess of fat accumulation. However, there is little BAT in adult humans. Therefore, UCP1 expression in tissues other than BAT is expected to reduce abdominal fat. Here, we show reduction of abdominal(More)
1 We have developed an approach to acquire complicated user optimization criteria and use them to guide iterative solution improvement. The effectiveness of the approach was tested on job shop scheduling problems. The ill-structuredness of the domain and the desired optimization objectives in real-life problems, such as factory scheduling, makes the(More)
Fucoxanthin has a unique structure including an unusual allenic bond and 5, 6-monoepoxide in its molecule. We found that abdominal white adipose tissue (WAT) weights of rats and mice fed fucoxanthin were significantly lower than those fed a control diet. The daily intake of fucoxanthin in mice also caused a significant reductions of body weight. Clear(More)
Adding knowledge to a knowledge-based system is not monotonically beneecial. We discuss and experimentally validate this observation in the context of CABINS, a system that learns control knowledge for iterative repair in ill-structured optimization problems. In CABINS , situation-dependent user's decisions that guide the repair process are captured in(More)
Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving this goal, several researchers have(More)
—Services are perishable and are simultaneously produced and consumed. A reservation is a traditional and effective means for coordinating service demand and supply. In recent years, computerized reservation systems have been used widely by many service vendors such as airline companies and hotels to satisfy their customers' demands and improve their(More)