Kazuo Kataoka

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Aquaporin-4 (AQP4) is a water channel protein that plays an important role in water movement in the central nervous system (CNS). Recently, presence of anti-AQP4 antibody has been reported in the sera from patients with neuromyelitis optica. AQP4 is therefore a possible target for inflammatory mechanisms in CNS. In the present investigation, we performed(More)
Activation of the peripheral protease-activated receptor-2 (PAR-2) triggers nociceptive behaviour and thermal hyperalgesia in rats. The present study created a novel mouse model for PAR-2-triggered nociception, and then examined the roles of NMDA receptors and the nitric oxide (NO) pathway in nociceptive processing by PAR-2. Intraplantar administration of(More)
Lymphomatoid granulomatosis (LYG) is a systemic granulomatous disease characterized by B-cell proliferation of uncertain malignant potential. It most frequently affects the lungs but also occasionally affects the central nervous system. Its pathophysiology is unclear in numerous respects, thus making it difficult to diagnose and treat. We recently(More)
Protease-activated receptors (PARs) 1 and 2 are expressed in capsaicin-sensitive sensory neurons, being anti- and pro-nociceptive, respectively. Given the possible cross talk between PAR-2 and capsaicin receptors, we investigated if PAR-2 activation could facilitate capsaicin-evoked visceral pain and referred hyperalgesia in the mouse and also examined the(More)
We aimed to demonstrate the effectiveness of fluorescence-guided surgery of metastatic brain tumors using fluorescein sodium. The study comprised 38 patients with metastatic brain tumors who underwent tumor resection after intravenous injection of fluorescein sodium. The local recurrence rate was investigated in 36 of the 38 patients, and compared for(More)
BACKGROUND Transfemoral stenting of stenoses at the common carotid artery (CCA) origin is technically difficult because of poor stability of the guiding catheter. OBJECTIVE To describe an anchoring technique using a balloon protection device that provides excellent stability of the guiding catheter. METHODS Four patients (5 stenotic lesions) with(More)
BACKGROUND Recently, endoscopic pituitary surgery is increasingly being used in pituitary surgery. Compared to conventional microscopic pituitary surgery, outcomes have been non-inferior, so endoscopic pituitary surgery has become an established surgical technique. However, this is a highly specialized surgery and sophisticated surgical techniques are(More)
BACKGROUND Many metastatic brain tumors have a distinct border with normal brain tissue, which facilitates tumor removal. However, residual tumor tissue may be present after surgery when metastatic brain tumors are of cystic type. We have developed a method using hydrofiber dressing to transform cystic-type into solid-type tumors. METHODS Hydrofiber(More)
Primary central nervous system lymphoma is generally treated with radiochemotherapy, but surgical treatment can be used in combination with biopsy. We used fluorescein Na to provide intraoperative fluorescence during biopsy to improve the safety and accuracy of surgical treatment. After dural incision, fluorescein Na was administered intravenously at 20(More)
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