Kazunori Yamaguchi

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The long non-coding RNA HOTAIR has been reported to be a poor prognostic biomarker in a variety of malignant tumors. However, little is known about the association of HOTAIR with gastric cancer. We examined the expression of HOTAIR in 68 gastric cancer samples using quantitative real-time RT-PCR and analyzed its correlation with the clinical parameters. The(More)
Aberrant glycosylation is a characteristic feature of cancer cells. In particular, altered sialylation is closely associated with malignant properties, including invasiveness and metastatic potential. To elucidate the molecular mechanisms underlying the aberrancy, our studies have focused on mammalian sialidase, which catalyzes the removal of sialic acid(More)
Inclusion 01 ADTs (AbsWacr Dula Types) has been studied by many researchers as a promising feature to make the relational database meet requirements from non-traditional advanced applications. In databases which support ADTs, the execution cost of a selection involving ADT functions (shortly, ADT selecdun) may be equal to or possibly more than that of a(More)
Plasma membrane-associated sialidase is a key enzyme for ganglioside hydrolysis, thereby playing crucial roles in regulation of cell surface functions. Here we demonstrate that mice overexpressing the human ortholog (NEU3) develop diabetic phenotype by 18-22 weeks associated with hyperinsulinemia, islet hyperplasia, and increased beta-cell mass. As compared(More)
Focused crawlers are considered as a promising way to tackle the scalability problem of topic-oriented or personalized search engines. To design a focused crawler, the choice of strategy for prioritizing unvisited URLs is crucial. In this paper, we propose a method using a decision tree on anchor texts of hyperlinks. We conducted experiments on the real(More)
Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human hypopharyngeal cancer (HPC) stem cells remain poorly understood. Here, we report that the CD271(+) population sorted from xenotransplanted HPCs possesses an enhanced tumor-initiating capability in immunodeficient mice. Tumors generated from the(More)
The neurons in the trigeminal ganglion (TG) are surrounded by satellite glial cells (SGCs), which passively support the function of the neurons, but little is known about the interactions between SGCs and TG neurons after peripheral nerve injury. To examine the effect of nerve injury on SGCs, we investigated the activation of SGCs after neuronal damage due(More)
We propose a method for the structural analysis of Web documentation. Employing the non-well-founded set theory, we have developed a means of reduction analysis to detect irregularities in the structures of target documents. To test this method's effectiveness, we applied it to Web-based educational materials in actual use and succeeded in identifying(More)