Kazunori Iwanaga

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UNLABELLED Myocardial imaging with 123I-metaiodobenzylguanidine (MIBG) was performed on 35 patients with Parkinson's disease and 24 control subjects to evaluate cardiac sympathetic function in patients with Parkinson's disease, verify this phenomenon and examine whether myocardial MIBG uptake and clearance are correlated with the clinical severity of(More)
Heart tissues of patients with PD or incidental Lewy body (LB) disease (ILBD) were examined by light and electron microscopy. LBs and alpha-synuclein-positive neurites were identified in the hearts from 9 of 11 patients with PD and from 7 of 7 patients with ILBD. LBs were present in both tyrosine hydroxylase-positive and -negative nerve processes, which are(More)
The objectives of this study were to characterize and compare the metabolic profile of cyclosporine A (CsA) catalyzed by CYP3A4, CYP3A5 and human kidney and liver microsomes, and to evaluate the impact of the CYP3A5 polymorphism on product formation from parent drug and its primary metabolites. Three primary CsA metabolites (AM1, AM9 and AM4N) were produced(More)
ヒ トの体 組 成測定 は,水 中体 重秤 量法 に代 表 され る 体 密 度 法 や 投 与 した重 水 の 希 釈率 に よる体 水 分 法 な ど,種 々 の方法 が提 唱 され て い る.近 年,生 体 の電 気 抵 抗 の大 きさが体 水 分 量 を反映 す る こ とを利 用 した測 定 法が 開発 され,米 国 を 中心 に 関連 の研 究報 告 が行 わ れて い る.こ の原理 に基づ く方法 としては,表 面 電極 に よって生体 の 電気 抵抗 を測 定す るイ ン ピー ダ ンス法 (Bioelectrical Impedance Analysis, BIA)と 全 身 を 磁 場 に暴 露 して 身 体 の 電 導 性 を 測 定 す るTOBEC (Total Body(More)
Surface electromyogram (EMG), blood pressure (BP), blink rate (BR) and heart rate (HR) were recorded before and during 4 types of mental task. The mental task involved 3 tasks that encompassed the memory (M), visual search (VS) and color-word (CW) tasks besides the control task (CT) of maintaining a similar posture while focusing on a single spot on the(More)
The purpose of this study was to investigate EEG changes in subjects directly after inhalation of essential oils, and subsequently, to observe any effect on subjective evaluations. EEG and sensory evaluation were assessed in 13 healthy female subjects in four odor conditions. Four odor conditions (including lavender, chamomile, sandalwood and eugenol) were(More)
Despite several studies suggesting that CYP3A5 expression can influence the extent of hepatic CYP3A-mediated inhibition, a systematic in vitro-in vivo evaluation of this potential clinically important issue has not been reported. Using representative probes from two distinct CYP3A substrate subgroups (midazolam, erythromycin), the inhibitory potency of(More)
The hypocalcemic effect of salmon calcitonin (sCT) after intravenous administration was explained on the basis of an integrated pharmacokinetic-pharmacodynamic (PK-PD) model with the endogenous Ca regulatory system in the rat. The pharmacokinetics of sCT described by a conventional two-compartment model showed the extremely rapid elimination of sCT from(More)
We performed post-mortem examinations of three patients with progressive neurogenic amyotrophy of long duration. One patient had been clinically diagnosed as having sporadic amyotrophic lateral sclerosis (ALS) and two had been diagnosed with progressive spinal muscular atrophy (PSMA). The disease durations were 10, 17 and 20 years, respectively, and all of(More)
We prepared two kinds of surface-coated liposomes and investigated their potencies as oral dosage forms for peptide drugs by focusing on their effects on the gastrointestinal (GI) transit of drugs. The surface of the liposomes was coated with poly(ethylene glycol) 2000 (PEG-Lip) or the sugar chain of mucin (Mucin-Lip). As a model peptide drug, insulin was(More)