Kazunari Ishii

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PURPOSE To explore any correlation between the number of previous gadolinium-based contrast material administrations and high signal intensity (SI) in the dentate nucleus and globus pallidus on unenhanced T1-weighted magnetic resonance (MR) images. MATERIALS AND METHODS The institutional review board approved this study, waiving the requirement to obtain(More)
OBJECTIVES To investigate the ability of T1 mapping of liver on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the estimation of liver function. MATERIALS AND METHODS Local institutional review board approved this study. Ninety-one patients (64 men, 27 women; mean age, 67.4 years) were(More)
Measurement of cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) by positron emission tomography (PET) with oxygen-15 labelled carbon dioxide (C15O2) or 15O-labelled water (H2 15O), 15O-labelled carbon monoxide (C15O) and 15O-labelled oxygen (15O2) is useful for(More)
BACKGROUND AND PURPOSE Voxel-based morphometry (VBM), used for detecting brain atrophy, permits comparison of local gray matter concentration at every voxel in an image between two groups. We sought to delineate the specific patterns of cerebral gray matter loss with regard to onset of Alzheimer's disease (AD) by using MR imaging and VBM and to evaluate the(More)
UNLABELLED The purpose of this study was to delineate the specific patterns of cerebral glucose metabolism with regard to the time of onset of Alzheimer's disease (AD). METHODS Two groups of 20 AD patients with different ages of onset were examined. The early onset (EO) and late onset (LO) groups had mean ages of onset of 53.9 and 72.7 years. Groups of(More)
Although decreased posterior cingulate metabolism in Alzheimer's disease (AD) has been previously reported, there have been no reports on posterior cingulate perfusion. In this study we evaluated posterior cingulate perfusion as a relative value using statistical parametric maps (SPMs) and as an absolute value using conventional region of interest (ROI)(More)
The aim of this study was to investigate the regional differences between the morphologic and functional changes in the same patients with frontotemporal dementia (FTD) using statistical parametric mapping and voxel-based morphometry (VBM). Thirteen FTD patients (mean age, 64.9 years old; mean MMSE score, 17.7), 20 sex-matched Alzheimer’s disease (AD)(More)
WSX-1 is a class I cytokine receptor with homology to the IL-12 receptors and is essential for resistance to Leishmania major infection. In the present study, we demonstrated that WSX-1 was also required for resistance to Trypanosoma cruzi. WSX-1-/- mice exhibited prolonged parasitemia, severe liver injury, and increased mortality over wild-type mice.(More)
The aim of this study was to investigate regional differences between morphologic and functional changes in the same patients with mild Alzheimer’s disease (AD) using statistical parametric mapping (SPM) and voxel-based morphometry (VBM). Thirty patients with very mild AD (mean age 66.8 years, mean MMSE score 24.0) and 30 age- and sex-matched normal(More)
The aim of this study was to evaluate the gender and age differences in the normal adult human brain, using voxel-based morphometry. In this study, 227 right-handed normal adults (male:female = 111:116) were examined. Three-dimensional magnetic resonance brain images of each subject were segmented into gray and white matter using statistical parametric(More)