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Diffuse malignant mesothelioma (DMM) is a tumor of serosal membranes with propensity for progressive local disease. Because current treatment options are largely ineffective, novel therapeutic strategies based on molecular mechanisms and the disease characteristics are needed to improve the outcomes of patients with this disease. Akt kinase interacting(More)
Malignant pleural mesothelioma (MPM) is a rare and highly aggressive neoplasm that arises from the pleural, pericardial, or peritoneal lining. Although surgery, chemotherapy, radiotherapy, and combinations of these therapies are used to treat MPM, the median survival of such patients is dismal. Therefore, there is a compelling need to develop novel(More)
The adult type of neuronal ceroid lipofuscinosis (NCL) occurred in a 49-year-old man and his 51-year-old sister. They showed episodic stuporous and psychotic states, mental retardation, generalized convulsions, and ichthyosis vulgaris. At autopsy the woman had excessive accumulation of lipofuscin throughout the CNS. The degree of neuronal lipopigment(More)
A 63-year-old woman showed the dominant clinical features of aphasia as the initial symptom in the course of presenile progressive dementia. Computerized axial tomography showed strikingly dilated Sylvian fissures, particularly in its posterior aspect, in the presence of moderate diffuse cortical atrophy. EEG revealed a slowdown in activity with the(More)
A case of a 44-year-old male with progressive subcortical gliosis was presented. The clinical manifestations included mental activity, difficulty in attention, euphoria and inability to work. The impairement of memory was not evident and his personality was fairly well preserved. Neurological examination showed no abnormality. The course was progressive(More)
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