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A transcription factor, Cbfa1, which belongs to the runt-domain gene family, is expressed restrictively in fetal development. To elucidate the function of Cbfa1, we generated mice with a mutated Cbfa1 locus. Mice with a homozygous mutation in Cbfa1 died just after birth without breathing. Examination of their skeletal systems showed a complete lack of(More)
Monkeys were trained to perform hand movements in a reaction time task with discrimination between positive (go) and negative (no-go) light signals, and field potentials in various cortical areas were recorded and analysed with chronically implanted cortical electrodes. As previously reported, areas such as the prefrontal, premotor and motor cortices were(More)
Two monkeys were trained to lift a lever with wrist extension in response to a visual cue. The animals were chronically implanted with electrodes for recording transcortical field potentials. Unique 'error' potentials were observed in the anterior cingulate cortical area 24 during a transitional learning-stage when the animals were uncertain about(More)
Senescence-accelerated mouse (SAMP8) is known as a murine model of accelerated aging and memory dysfunction. The binding activity of [3H] 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxam ide (PK-11195) as a neurochemical marker of gliosis markedly increased with aging in the cerebral cortex and hippocampus of SAMP8. Immunoreactivity for(More)
OBJECTIVE We examined the association between diabetes-related factors and pathology of Alzheimer disease (AD) to evaluate how diabetes affects the pathogenic process of AD. METHODS This study included specimens from a series of 135 autopsies of residents of the town of Hisayama in Fukuoka prefecture (74 men and 61 women) performed between 1998 and 2003,(More)
Ninety-two patients with pituitary adenomas have been treated during the last 5 years. Sixty-three of these patients had more than 6 months follow-up, and they form the basis of this report. Eighteen had non-functioning adenomas (NFA), and 36 had functioning adenomas (FA). The mean marginal dose was 22.5 Gy (NFA 19.5 Gy, FA 23.9 Gy). Control of tumor growth(More)
Our MEG studies on the human frontal association cortex are briefly reviewed. (1) The no-go potential was first found at go/no-go reaction-time hand movement task with discrimination between different colour light stimuli in the prefrontal cortex of monkeys. The potential was recorded in human subjects with EEG over the scalp, but its current dipoles could(More)
Frontal mental theta waves were recorded simultaneously with magnetoencephalography (MEG) and electroencephalography (EEG) in normal subjects. MEG analyses demonstrated that theta burst activities distribute widely in the frontal cortices of both the cerebral hemispheres during concentration on mental calculation. On the other hand, EEG showed the theta(More)
(1) Functional commencements of the neuronal elements in the cerebellar cortex of young rats were studied electrophysiologically by means of laminar field potential analyses in the cortex on stimulation of the cerebellar surface (Loc) and the white matter (WM). (2) The antidromic action potential of Purkinje cells on the WM stimulation was observed at one(More)
'No-go potential', specific to the no-go reaction in go/no-go reaction-time hand movement with discrimination between different colour light stimuli, was recorded with electrodes chronically implanted in the prefrontal cortex of monkeys. Similar potentials were widely distributed over frontal-parietal parts of the human scalp on the same no-go reaction. In(More)