• Publications
  • Influence
Efficacy of Favipiravir (T-705) in Rabies Postexposure Prophylaxis
TLDR
It is suggested that T-705 is active against RABV and may serve as a potential alternative to rabies immunoglobulin in rabies postexposure prophylaxis. Expand
Serial passage of a street rabies virus in mouse neuroblastoma cells resulted in attenuation: potential role of the additional N-glycosylation of a viral glycoprotein in the reduced pathogenicity of
TLDR
An attenuated variant of street rabies virus strain 1088, originating from a rabid woodchuck followed by 2 passages in the brains of suckling mice, is established and it is proposed that the number of N-glycosylation sites in the G protein is one of the determinants of the pathogenicity ofStreet rabies viruses. Expand
Addition of a single N-glycan to street rabies virus glycoprotein enhances virus production.
TLDR
It is demonstrated that single-N-glycan additions to the G protein of street rabies virus strain 1088, which are found in adapted strains, enhanced virus production in neural and non-neural cell lines, while additions to Asn (194) or Asn(247) enhanced production greatly. Expand
Evaluation of Rapid Neutralizing Antibody Detection Test against Rabies Virus in Human Sera
TLDR
Assessment of the RAPINA test by comparison with rapid focus fluorescence inhibition test (RFFIT), using 214 sera of vaccinated and unvaccinated professional dog butchers, laboratory workers and rabies patients in Vietnam found remarkable sensitivity, specificity and easy implementation. Expand
Isolation and characterization of novel human monoclonal antibodies possessing neutralizing ability against rabies virus
TLDR
Two novel huMabs which neutralize rabies virus were established from vaccinated hyperimmune volunteers using the Epstein‐Barr virus transformation method and are expected to be utilized as a tool for future post‐exposure prophylaxis. Expand
Reevaluation of the efficacy of favipiravir against rabies virus using in vivo imaging analysis.
TLDR
Bioluminescence imaging results support the hypothesis that favipiravir is effective in infected mice when RABV replicates in the peripheral tissues/nerves but not after virus neuroinvasion and suggest that a highly effective drug-delivery system into the CNS and/or the enhancement of favipiralavir conversion to its active form are required to improve favipIRavir treatment of rabies. Expand
Efficient N-glycosylation at position 37, but not at position 146, in the street rabies virus glycoprotein reduces pathogenicity.
TLDR
Analysis of two novel N-glycosylation-modified variants cloned using the limiting dilution method provide additional evidence that supports the relationship between G protein N- glycosylations and rabies virus evolution. Expand
Characterization of street rabies virus variants with an additional N-glycan at position 247 in the glycoprotein
TLDR
Both street virus strain 1088 variants exhibited highly efficient replication in mouse neuroblastoma-derived NA cells and reduced pathogenicity in adult mice when inoculated intramuscularly, but not intracerebrally, however, this attenuation was not attributable to the induction of strong immune responses. Expand
Near-infrared fluorescent protein iRFP720 is optimal for in vivo fluorescence imaging of rabies virus infection.
TLDR
Comparison testing of far-red and NIR FPs in the imaging of rabies virus (RABV) infection concludes that the NIR FP iRFP720 used with a filter set for >700 nm is useful for in vivo fluorescence imaging not only for RABV infection but also for other virus infections. Expand
Validation of serum apolipoprotein A1 in rabies virus-infected mice as a biomarker for the preclinical diagnosis of rabies.
TLDR
It was reported that ApoA1 was found to be a biomarker for neuronal damage and additional biomarker candidates will be needed for the effective preclinical diagnosis of rabies. Expand