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BACKGROUND The purpose of this study was to retrospectively compare the volume doubling time (VDT) on serial computed tomography (CT) of non-small-cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation with that of NSCLC without the mutation. METHODS One hundred and two pathologically proven NSCLCs, including 69 patients with lung(More)
To investigate the mechanisms of the hypolipidemic effect ofmonatepil, a new class of calcium antagonists withα1-adrenergic blocking activity, we examined theeffects of the drug on low-density lipoprotein (LDL) receptor activity andthe level of LDL receptor mRNA present in cultured human skin fibroblasts.At concentrations of 2 × 10−5M, monatepilincreased(More)
More than one hundred monks belonging to Nichirenshu, a major Buddhist sect in Japan, participated in the annual hundred days austerities during the winter. Cold water bathing, insufficient sleep, hunger and emotional impact are considered to be the major Stressors experienced by the monks subjected to these austere regimes. This study was conducted to(More)
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