Kazuki Moriya

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Group II chaperonins play important roles in protein homeostasis in the eukaryotic cytosol and in Archaea. These proteins assist in the folding of nascent polypeptides and also refold unfolded proteins in an ATP-dependent manner. Chaperonin-mediated protein folding is dependent on the closure and opening of a built-in lid, which is controlled by the ATP(More)
Chaperonins are ubiquitous molecular chaperones with the subunit molecular mass of 60kDa. They exist as double-ring oligomers with central cavities. An ATP-dependent conformational change of the cavity induces the folding of an unfolded protein that is captured in the cavity. In the group I chaperonins, which are present in eubacteria and eukaryotic(More)
Automatic recognition of activities of daily living (ADL) can be applied to realize services to support user life such as elderly monitoring, energy-saving home appliance control, and health support. In particular, “real-time” ADL recognition is essential to realize such a service that the system needs to know the user's current activity.(More)
Recently, IoT (Internet of Things) technologies have been attracting increasing attention. Among many applications of IoT, homes can be the most promising target. One of the purposes to deploy IoT in homes is automatic recognition of activities of daily living (ADLs). It is expected that ADL recognition in homes enables many new services such as elderly(More)
Group II chaperonin captures an unfolded protein while in its open conformation and then mediates the folding of the protein during ATP-driven conformational change cycle. In this study, we performed kinetic analyses of the group II chaperonin from a hyperthermophilic archaeon, Thermococcus sp. KS-1 (TKS1-Cpn), by stopped-flow fluorometry and stopped-flow(More)
Recently, there are many studies on automatic recognition of activities of daily living (ADL) to provide various services such as elderly monitoring, intelligent concierge, and health support. In particular, real-time ADL recognition is essential to realize an intelligent concierge service since the service needs to know user's current or next activity for(More)
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