Kazuhisa Okuda-Akabane

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In this study, we investigated the functional difference between chemical stimulations of the posterior tongue (PT) and pharyngeal region (PR) for facilitation of voluntary swallowing in humans. The PT or PR stimulation consisted of infusion of water (distilled water), 0.3 M NaCl solution or olive oil (non-chemical stimulant) into the PT or the PR through a(More)
Stimulation of water receptors in the laryngopharynx (LP) with water facilitates voluntary swallowing in humans. Based on measures of swallowing intervals (SIs) in repetitive swallowing, we investigated characteristics of laryngopharyngeal water receptors in humans. Healthy adult volunteers were instructed to perform repetitive swallowing as quickly as(More)
In frogs, the responses of the glossopharyngeal nerve (GL) to NaCl are enhanced after treatment of the tongue with 8-anilino-1-naphthalene-sulfonic acid (ANS), a hydrophobic probe for biological membranes. The enhancement by ANS treatment has been explained by removal of Ca2+ from the receptor membrane treated with ANS. To explore the mechanism of(More)
The frog tongue has a disc-shaped taste organ (taste disc) on the top of fungiform papillae. The taste disc contains two types of cells, wing cells with a sheet-like apical process and rod cells with a rod-like apical process. Both wing and rod cells can produce action potentials. Unlike the taste buds of mammals, frog taste discs do not degenerate over a(More)
In frogs, the glossopharyngeal nerve (GL) innervates taste receptors on almost the entire tongue. The mandibular branch (MBF) and palatine branch (PN) of the facial nerve innervate taste receptors on a very small area at the base of the tongue and on the palate, respectively. In the present study, effects of amiloride, an epithelial sodium channel blocker,(More)
The aim of this investigation was to study the characteristics of hyperalgesia and inflammatory change in the craniofacial area following the production of an acute arthritis of the temporomandibular joint (TMJ) in the rabbit. Unilateral arthritis was produced by the injection of monosodium urate (MSU) into the TMJ of the rabbits. Hyperalgesia was evaluated(More)
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