Kazuhiro Kashiwagi

We don’t have enough information about this author to calculate their statistics. If you think this is an error let us know.
Learn More
Tight control of protein synthesis is necessary for cells to respond and adapt to environmental changes rapidly. Eukaryotic translation initiation factor (eIF) 2B, the guanine nucleotide exchange factor for eIF2, is a key target of translation control at the initiation step. The nucleotide exchange activity of eIF2B is inhibited by the stress-induced(More)
Eukaryotic cells restrict protein synthesis under various stress conditions, by inhibiting the eukaryotic translation initiation factor 2B (eIF2B). eIF2B is the guanine nucleotide exchange factor for eIF2, a heterotrimeric G protein consisting of α-, β- and γ-subunits. eIF2B exchanges GDP for GTP on the γ-subunit of eIF2 (eIF2γ), and is inhibited by(More)
A 64-year-old man was referred to our hospital due to anemia and occult gastrointestinal bleeding. Small bowel barium enteroclysis revealed a well-rounded, semi-pedunculated protrusion, covered with a smooth surface, appearing to be a soft filling defect at the distal ileum measuring 20 mm in diameter (Picture 1). Next, balloon en-teroscopy showed the(More)
The eukaryotic translation initiation factor 2A (eIF2A) was identified as a factor that stimulates the binding of methionylated initiator tRNA (Met-tRNA i Met ) to the 40S ribosomal subunit, but its physiological role remains poorly defined. Recently, eIF2A was shown to be involved in unconventional translation initiation from CUG codons and in viral(More)
  • 1