Kazuhiro Hashimoto

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Most nemaline myopathy patients have mutations in the nebulin (NEB) or skeletal muscle alpha-actin (ACTA1) genes. Here we report for the first time three patients with severe nemaline myopathy and mutations of the ACTA1 stop codon: TAG>TAT (tyrosine), TAG>CAG (glutamine) and TAG>TGG (tryptophan). All three mutations will cause inclusion of an additional 47(More)
Mutations in the epidermal growth factor receptor (EGFR) gene are associated with a favorable clinical response to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib in non-small cell lung cancer (NSCLC). We present here, a new method for the rapid detection of the two most common EGFR mutations (delE746-A750 and L858R) from clinical samples. The(More)
Processors designed for computer entertainment must perform 3D graphics calculations, especially geometry and perspective transformations. In the PlayStationR2, we introduced the new idea of synthesizing emotion called Emotion Synthesis and devised a new processor architecture to support its graphics demands. The architecture is embodied in the(More)
Design methodologies and CAD for " Emotion Engine " LSI are presented with emphasis on practical aspects of verification and timing closure. A combination of simulation, emulation and formal verification ensured the functional first silicon for system evaluation. In order to control wire delay in early design stage, floor-plan based synthesis and wire load(More)
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