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To elucidate the hidden dynamics of extracellular-signal-regulated kinase (ERK) signalling networks, we developed a simulation model of ERK signalling networks by constraining in silico dynamics based on in vivo dynamics in PC12 cells. We predicted and validated that transient ERK activation depends on rapid increases of epidermal growth factor and nerve(More)
To enhance the mobility of amphibious robots for multi-terrains tasks, we have proposed an eccentric paddle locomotion mechanism (ePaddle) with several feasible terrestrial and aquatic gaits. In this paper, we present a rigid paddle model for predicting the thrust force in one of the aquatic gaits, namely the rotational paddling gait. Thrust forces(More)
A new information technology called Distributed Virtual Environment or DVE is applied to English education for Japanese engineering students. The system is not a teaching tool for new knowledge of English but it provides computer augmented virtual places where students get together and work in cooperation in the target foreign language on some topical(More)
Osteoporosis with bone loss is widely recognized as a major health problem. Bone homeostasis is maintained by balancing bone formation and bone resorption. The imbalance caused by increased bone resorption over bone formation can lead to various bone-related diseases such as osteoporosis and rheumatoid arthritis. Osteoclasts are the principal cells(More)
It is becoming hard to produce designs when developing electronic equipment because of advances in packaging technology and strict regulations. It is specifically difficult to conform to electromagnetic compatibility (EMC) standards in the design phase. And this is a factor that causes development costs to increase. By implementing a simulation for virtual(More)
The purpose of this research is to develop a system for supporting dance. We have developed a database system for fundamental steps of classical ballet to manage and to utilize 3-dimensional motion data. First, we archived 543 fundamental steps obtained by motion capture systems, then constructed a 3-dimensional motion database for them. A user can search(More)
This paper presents multiscale modeling of electromagnetic interaction between a short relativistic electron bunch and long resistive structures at cryogenic temperatures. The considered physical problems include multiple spatial scales such as structure, bunch size, and skin depth. In order to simulate such multiscale problems, a directionally implicit(More)
This paper presents FDTD-SPICE direct linking simulations of transient electromagnetic fields caused by electrostatic discharges (ESD) in general structures. Especially, the air-discharge ESD simulation is performed by simultaneously combining a full-wave model for structures of analytical objects and SPICE equivalent circuit models based on nonlinear spark(More)