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To elucidate the hidden dynamics of extracellular-signal-regulated kinase (ERK) signalling networks, we developed a simulation model of ERK signalling networks by constraining in silico dynamics based on in vivo dynamics in PC12 cells. We predicted and validated that transient ERK activation depends on rapid increases of epidermal growth factor and nerve(More)
The antiferromagnetic ground state of copper oxide Mott insulators is achieved by localizing an electron at each copper atom in real space (r-space). Removing a small fraction of these electrons (hole doping) transforms this system into a superconducting fluid of delocalized Cooper pairs in momentum space (k-space). During this transformation, two(More)
Many theoretical models of high-temperature superconductivity focus only on the doping dependence of the CuO(2)-plane electronic structure. However, such models are manifestly insufficient to explain the strong variations in superconducting critical temperature, T(c), among cuprates that have identical hole density but are crystallographically different(More)
An energy gap is, in principle, a dominant parameter in superconductivity. However, this view has been challenged for the case of high-Tc cuprates, because anisotropic evolution of a d-wave-like superconducting gap with underdoping has been difficult to formulate along with a critical temperature Tc. Here we show that a nodal-gap energy 2ΔN closely follows(More)
: The doping-dependent evolution of the d-wave superconducting state is studied from the perspective of the angle-resolved photoemission spectra of a high-Tc cuprate, Bi2Sr2CaCu2 O8+δ (Bi2212). The anisotropic evolution of the energy gap for Bogoliubov quasiparticles is parametrized by critical temperature and superfluid density. The renormalization of(More)
It has been predicted that superconducting vortices should be electrically charged and that this effect is particularly enhanced for high-temperature superconductors 1,2. Hall effect 3 and nuclear magnetic resonance (NMR) experiments 4 suggest the existence of charge accumulation in the vortex core, but the effects are small and the interpretation(More)
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