Kazuhiko Yamaguchi

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The formation and maintenance of polarized distributions of membrane proteins in the cell membrane are key to the function of polarized cells. In polarized neurons, various membrane proteins are localized to the somatodendritic domain or the axon. Neurons control polarized delivery of membrane proteins to each domain, and in addition, they must also block(More)
Here we provide evidence that astrocytes affect neuronal synaptogenesis by the process of adhesion. Local contact with astrocytes via integrin receptors elicited protein kinase C (PKC) activation in individual dissociated neurons cultured in astrocyte-conditioned medium. This activation, initially focal, soon spread throughout the entire neuron. We then(More)
For decoding low-density parity-check (LDPC) codes on discrete memoryless channels, a method to quantize messages and to find message-passing decoding functions for the variable and check nodes is developed. These are used to obtain noise thresholds by density evolution. The messagepassing decoding alphabet is restricted to be discrete with a fixed maximum(More)
The Rab3 GDP/GTP exchange protein (Rab3 GEP) activates the Rab3 small GTP-binding protein (G protein) family, including Rab3A that is an important member controlling synaptic vesicle trafficking. Here, we examined the role of Rab3 GEP in regulating neurotransmitter release in autapses of mouse hippocampal neurons in culture. The release probability was(More)
Collapsin response mediator protein 5 (CRMP5) is one of the CRMP members that expresses abundantly in the developing brain. To examine the in vivo function of CRMP5, we generated crmp5-deficient (crmp5(-/-)) mice. Anti-calbindin immunofluorescence studies of crmp5(-/-) mice revealed aberrant dendrite morphology; specifically, a decrease in the size of soma(More)
Long-term depression (LTD) here concerned is persistent attenuation of transmission efficiency from a bundle of parallel fibers to a Purkinje cell. Uniquely, LTD is induced by conjunctive activation of the parallel fibers and the climbing fiber that innervates that Purkinje cell. Cellular and molecular processes underlying LTD occur postsynaptically. In the(More)
1. Field potentials in the olfactory bulb and intracellular potentials from mitral cells were analyzed in the carp. Electrical shocks were applied to a part of the input (the lateral or medial bundle of the olfactory nerve: l-ON or m-ON respectively) or output pathways (lateral or medial olfactory tract: LOT or MOT respectively) of the olfactory bulb in(More)
Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single climbing fiber axon from the inferior olive that extend along Purkinje dendrites, and parallel fiber(More)
For the digital watermarking patchwork algorithm originally given by Bender et al., this paper proposes two improvements applicable to audio watermarking. First, the watermark embedding strength is psychoacoustically adapted, using the Bark frequency scale. Second, whereas previous approaches leave the samples that do not correspond to the data untouched,(More)
mRNA transport and local translation in dendrites play key roles in use-dependent synaptic modification and in higher-order brain functions. RNG105, an RNA-binding protein, has previously been identified as a component of RNA granules that mediate dendritic mRNA localization and local translation. Here, we demonstrate that RNG105 knock-out in mice reduces(More)