Kazuhiko Machida

Hideki Tsutsumi3
Norio Ishigaki2
Naoyuki Nishimura2
3Hideki Tsutsumi
2Norio Ishigaki
2Naoyuki Nishimura
2Nobuhide Ogihara
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The application of carbon nanotubes (CNTs) as biomaterials is of wide interest, and studies examining their application in medicine have had considerable significance. Biological safety is the most important factor when considering the clinical application of CNTs as biomaterials, and various toxicity evaluations are required. Among these evaluations,(More)
BACKGROUND Although the number of circulating immune cells is subject to high-amplitude circadian rhythms, the underlying mechanisms are not fully understood. METHODS To determine whether intact CLOCK protein is required for the circadian changes in peripheral blood cells, we examined circulating white (WBC) and red (RBC) blood cells in homozygous Clock(More)
BACKGROUND Alveolar epithelial cells are known as progenitor cells for the restoration from the damage in the lung. Calcitonin gene-related peptide (CGRP) has been reported to play an important role in the proliferation of various types of epithelial and endothelial cells. We investigated the effects of CGRP on the proliferation of alveolar epithelial cells(More)
Psychological stress or life events might significantly decrease neutrophil function in elderly individuals and lead to infectious diseases. However, relationships between these factors have not been examined in detail. We investigated the relationships between neutrophil function measured using the nitroblue tetrazolium (NBT) reduction test and(More)
An animal model for the early detection of common fatal diseases such as ischemic diseases and cancer is desirable for the development of new drugs and treatment strategies. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in a number of diseases, including cancer. Here, we established(More)
In this paper, we propose an input support system which supports multiple languages and which will make it possible for users-- even users who are in the midst of learning a foreign language that they wish to use and are not familiar with it yet--to easily access the information resources in their desired language. As a text input method that is not(More)
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