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Hydroxyeicosanoids Bind to and Activate the Low Affinity Leukotriene B4 Receptor, BLT2*
- T. Yokomizo, Kazuhiko Kato, H. Hagiya, T. Izumi, Takao Shimizu
- BiologyThe Journal of Biological Chemistry
- 13 April 2001
It is suggested that BLT2 functions as a low affinity receptor, with broader ligand specificity for various eicosanoids, and mediates distinct biological and pathophysiological roles from BLT1.
A Second Leukotriene B4 Receptor, Blt2
- T. Yokomizo, Kazuhiko Kato, K. Terawaki, T. Izumi, Takao Shimizu
- BiologyThe Journal of Experimental Medicine
- 7 August 2000
The molecular cloning of a novel GPCR for LTB4, designated BLT2, is reported, which binds L TB4 with a Kd value of 23 nM compared with 1.1 nM for BLT1, but still efficiently transduces intracellular signaling.
Cell-Specific Transcriptional Regulation of Human Leukotriene B4 Receptor Gene
- Kazuhiko Kato, T. Yokomizo, T. Izumi, Takao Shimizu
- BiologyThe Journal of experimental medicine
- 7 August 2000
The genomic structure and a promoter analysis of the human BLT1 gene and the first example of “promoter in ORF” in higher eukaryotes are reported, with an emphasis on the mechanism of cell-specific transcription.
Palladium-Catalyzed Enantioselective Carbonylative Cyclization of Aryl and Alkenyl Triflates with Carbon Monoxide
A catalyst system based on Pd(OCOCF3)2/(S)-binap has been established to effect asymmetric carbonylative cyclization of prochiral o-allylaryl triflates and 2-allylalkenyl triflates with carbon…
Design and Preparation of 3,3'-Disubstituted 2,2'-Bis(oxazolyl)-1,1'-binaphthyls (boxax): New Chiral Bis(oxazoline) Ligands for Catalytic Asymmetric Wacker-Type Cyclization.
- Y. Uozumi, Hirokazu Kyota, Kazuhiko Kato, M. Ogasawara, Tamio Hayashi
- ChemistryThe Journal of organic chemistry
- 17 February 1999
New optically active 2,2'-bis(oxazolyl)-1,1'-binaphthyls (boxax) bearing various substituents at their C3 and C3' positions showed much higher enantioselectivity than the 3,3'-unsubstituted ones in the palladium(II)-catalyzed Wacker-type cyclization of an o-allylphenol.
CATIONIC PALLADIUM/BOXAX COMPLEXES FOR CATALYTIC ASYMMETRIC WACKER-TYPE CYCLIZATION
Catalyticasymmetric Wacker-type cyclization of 2-(2,3-dimethyl-2-butenyl)phenol (1a) was efficiently catalyzed by 1 or 2 mol % of a cationic palladium−boxax complex generated in situ by mixing…
Asymmetric aza-Claisen rearrangement of allyl imidates catalyzed by homochiral cationic palladium(II) complexes
Synthesis and application of novel chiral phosphino-oxazoline ligands with 1,1′-binaphthyl skeleton
Synthetic studies on mitotic kinesin Eg5 inhibitors: synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives.
Prognostic significance of red cell distribution width in hospitalized older patients with heart failure or infection
- Keitaro Nakashima, E. Ohgami, Kazuhiko Kato, Souichi Yoshitomi, T. Maruyama, M. Harada
- MedicineGeriatrics & gerontology international
- 1 October 2019
The aim of the present study was to investigate the prognostic role of RDW in older adults hospitalized for the treatment of heart failure or infection, because both diseases are fatal, especially in the geriatric population.