Kazuaki Fukushima

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The medial prefrontal cortex (mPFC) has been proposed to be essential for extinction of fear memory, but its neural mechanism has been poorly understood. The present study examined whether synaptic transmission in the hippocampal-mPFC pathway is related to extinction of context-dependent fear memory in freely moving rats using electrophysiological(More)
In order to clarify the mechanism by polyphenols of protective effects against oxidative damage or by quinolinic acid of its neurotoxic and inflammatory actions, effects of polyphenols or quinolinic acid on the radical formation were examined. The ESR measurements showed that some polyphenols such as caffeic acid, catechol, gallic acid, D-(+)-catechin,(More)
We have previously reported that a dynamic balance test with perturbation stimuli and computerised dynamic posturography sensitively reflected the inhibitory effect on balance of intravenous midazolam sedation given intravenously as a single dose, and recovery time was within 80 min. The purpose of this study was to investigate the recovery of dynamic(More)
The aim of the present study was to examine whether early postnatal stress during brain development alters the synaptic response to emotional stress, focusing on the behavioral expressions to contextual fear conditioning (CFC) at postadolescnece. Pups were exposed to an aversive stimulus, foot shock (FS), at the postnatal period of the second week (2w-FS)(More)
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