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  • Kayoko Ohura, Hisae Sakamoto, Shin-ichi Ninomiya, Teruko Imai
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • 2010 (First Publication: 1 February 2010)
  • Both mRNA and protein levels of the carboxylesterase (CES) isozymes, hCE1 and hCE2, in Caco-2 cells increase in a time-dependent manner, but hCE1 levels are always higher than those of hCE2. In humanExpand
  • Kayoko Ohura, Takaaki Nozawa, Koichi Murakami, Teruko Imai
  • Medicine, Chemistry
  • Journal of pharmaceutical sciences
  • 2011 (First Publication: 1 September 2011)
  • The intestinal absorption mechanism of temocapril, an ester-type prodrug of temocaprilat, was evaluated using Caco-2 cell monolayers with or without active carboxylesterase (CES)-mediated hydrolysis.Expand
  • Michiya Matsusaki, Daichi Hikimoto, +4 authors Mitsuru Akashi
  • Medicine, Biology
  • Biochemical and biophysical research…
  • 2015 (First Publication: 13 February 2015)
  • Caco-2, human colon carcinoma cell line, has been widely used as a model system for intestinal epithelial permeability because Caco-2 cells express tight-junctions, microvilli, and a number ofExpand