Kayako Matsuyama

Learn More
CONTEXT Pigment epithelium-derived factor (PEDF) is a strong inhibitor of angiogenesis. Eyes with diabetic retinopathy have low levels of ocular PEDF; however, the PEDF levels in the blood of diabetics have still not been determined. OBJECTIVES Our objective was to determine the plasma levels of PEDF in diabetic patients and to determine the relationship(More)
PURPOSE Diabetic retinopathy and nephropathy are microvascular complications in patients with diabetes that are considered to be related. Pigment epithelium-derived factor (PEDF), a strong inhibitor of angiogenesis, is significantly elevated in the blood of diabetic patients, especially those with proliferative diabetic retinopathy (PDR). The level of PEDF(More)
Bevacizumab is a human monoclonal IgG1 antibody that blocks the action of vascular endothelial growth factor (VEGF). The purpose of this study was to determine the level of VEGF and pigment epithelium-derived factor (PEDF) in eyes with proliferative diabetic retinopathy (PDR) before and after an intravitreal injection of bevacizumab. Eleven eyes of ten(More)
PURPOSE Whether an intravitreal injection of bevacizumab in 1 eye will have any effect on the fellow eye has been discussed. The aim of this study was to determine the level of vascular endothelial growth factor (VEGF) in the fellow eyes after an intravitreal injection of bevacizumab in 1 eye with proliferative diabetic retinopathy. METHODS Eight patients(More)
culture studies were negative. A diagnostic biopsy was performed, and the white mass from the anterior chamber was examined. Although the smear staining showed no fungal elements, systemic and topical fl uconazole eight times/day and topical pimaricin eight times/day were given on the assumption that the endophthalmitis was fungal in origin. After 5 days,(More)
PURPOSE Large diurnal intraocular pressure (IOP) fluctuation ([INCREMENT]IOP) is believed to be one of the causes of progression in glaucomatous changes. Some fully medicated glaucoma patients whose IOPs are controlled during the regular office hours (10:00 to 16:00 h) still have progression in glaucomatous changes and IOP elevation during off-office hours.(More)
To determine whether a posterior sub-Tenon injection of triamcinolone acetonide (TA) before focal photocoagulation is safe and effective in patients with diabetic macular edema. Sixteen eyes of 11 diabetic patients with unresolved diffuse macular edema were treated with a 20-mg sub-Tenon injection of TA 1 to 2 months before focal photocoagulation. Focal(More)
BACKGROUND To determine whether the intraocular pressure (IOP) in diabetic patients is significantly different from that in nondiabetic patients. METHODS The medical records of all patients who were initially examined in the Department of Ophthalmology, Kansai Medical University, Takii Hospital were reviewed. At the initial examination, patients had a(More)
PURPOSE We examined the effectiveness of latanoprost for reducing intraocular pressure (IOP) in Japanese patients with normal tension glaucoma (NTG) over a 5-year period. DESIGN Prospective interventional case series. The patients were classified into 2 groups based on mean IOP. METHODS A total of 38 patients with NTG were studied after being classified(More)
BACKGROUND The purpose of this study was to determine the clinical features of patients with type 2 diabetes, and less ophthalmic examinations, referred by general physicians to ophthalmologists. METHODS The medical charts of 327 patients with type 2 diabetes referred to our department from general physicians were reviewed. A detailed medical history was(More)