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Mutations were introduced into the ectodomain of the human immunodeficiency virus type 1 (HIV-1) transmembrane envelope glycoprotein, gp41, within a region immediately adjacent to the membrane-spanning domain. This region, which is predicted to form an alpha-helix, contains highly conserved hydrophobic residues and is unusually rich in tryptophan residues.(More)
We have examined mutations in the ectodomain of the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 within a region immediately adjacent to the membrane-spanning domain for their effect on the outcome of the fusion cascade. Using the recently developed three-color assay (I. Muñoz-Barroso, S. Durell, K. Sakaguchi, E. Appella, and R.(More)
Acknowledgments I would like to thank my advisor Prof. Dr. Friedhelm Meyer auf der Heide for his support over the last three years. He gave me the freedom to choose the direction of my research and to my evolvement. Furthermore, I thank my wife Marlies Tenten for reading this thesis and for her psychological support. I am grateful to Matthias Fischer for(More)
In this paper we study the problem of designing compact, adaptive strategies for the distribution of objects among a heterogeneous set of servers. Ideally, such a strategy should allow the computation of the position of an object with a low time and space complexity, and it should be able to adapt with a near-minimum amount of replacements of objects to(More)
In the last couple of years a dramatic growth of enterprise data storage capacity can be observed. As a result, new strategies have been sought that allow servers and storage being centralized to better manage the explosion of data and the overall cost of ownership. Nowadays, a common approach is to combine storage devices into a dedicated network that is(More)
In this paper we study the problem of designing compact, adaptive strategies for the distribution of objects among a heterogeneous set of servers. Ideally, such a strategy should allow the computation of the position of an object with a low time and space complexity, and it should be able to adapt with a near-minimum amount of replacements of objects to(More)
The advances in network technology and the growth of the Internet together with upcoming new applications like peer-to-peer (P2P) networks have led to an exponential growth of the stored data volume. The key to manage this data explosion seems to be the consolidation of storage systems inside storage area networks (SANs) and the use of a storage(More)
Four chimeric human immunodeficiency virus type 1 (HIV-1) env genes were constructed which encoded the extracellular domain of either the wild-type or a cleavage-defective HIV-1 envelope glycoprotein (gp160) fused at one of two different positions in env to a C-terminal glycosyl-phosphatidylinositol (GPI) attachment signal from the mouse Thy-1.1(More)