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In recent years there has been considerable research and clinical interest in developing instruments to assess social supports available to individuals. There is, however, a notable deficiency of attempts to evaluate the psychometric properties of these questionnaires. The present article describes efforts made to evaluate the properties of a Social(More)
BACKGROUND A recent report demonstrated the immunogenic character of the cysteine proteinases of Trichomonas vaginalis. It was of interest, therefore, to examine for the presence of serum anti-proteinase antibody among patients with trichomoniasis. METHODS An immunoprecipitation assay was used involving protein A-bearing Staphylococcus aureus first coated(More)
Isoelectric focusing and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) with acrylamide copolymerized with gelatin (substrate-SDS-PAGE) were combined to evaluate the proteinases of both long-term-grown and fresh isolates of Trichomonas vaginalis. This two-dimensional substrate-SDS-PAGE resolved as many as 23 distinct proteinase(More)
This article described experience with the use of health diaries in a two-year prospective study of the influence of the psychosocial environment on the health status of 500 subjects in the Hamilton area. Three strategies were used to maintain compliance: 1) random sampling of three days within each two-week interval; 2) a lottery ticket incentive; and 3)(More)
In a study looking at the relationship of life stress events to health status, 500 individuals randomly selected from family practices in Hamilton, Ontario were asked to keep a health diary for three days every two weeks over a two year period. The compliance with diary keeping was remarkably high (85%), partly due to a novel method of reinforcing(More)
Guidelines are presented for the establishment of a regional or national register of patients with familial adenomatous polyposis. The detailed recommendations are based on the work in committees of the “Leeds Castle Polyposis Group” and the “EuroFAP”. The aims of national and regional polyposis registers are discussed, and the stages of development of a(More)
Solubilization of live Trichomonas vaginalis organisms with detergent caused the release of cysteine proteinases in the detergent extract which were inhibitable with N-alpha-p-tosyl-L-lysine chloromethyl ketone. The detergent extracts of all isolates tested possessed similar cysteine proteinase activities. These parasite proteinases rapidly degraded a(More)
On 16 February 1983, a very pretty young woman with dark hair and sparkling brown eyes walked into Ian Todd’s consulting room. Mr Todd was the senior surgeon at St Mark’s Hospital (see Figure 1) and the patient had been referred to him because, in addition to having FAP, she had in her belly a large desmoid tumour. She had continued to work despite the(More)
The first convincing case of familial adenomatous polyposis was published 120 years ago, and in the first half of this period the disease was primarily described and managed by surgeons and pathologists. Since the discovery of the APC gene, familial adenomatous polyposis has changed into a disease, which is nowadays diagnosed, treated and controlled by a(More)