Kay H. Singer

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The skin is an important site for immunological reactions (1-3). Cutaneous infiltration by T lymphocytes is characteristic of a number of disease states and T lymphocytes have been observed within the epidermal compartment in graft-vs.-host disease (4), lichen planus (5), and delayed-type hypersensitivity (6). In addition, a heterogeneous group of T(More)
Binding of anti-cell surface pemphigus autoantibodies to cultured human epidermal cells stimulates synthesis and secretion of plasminogen activator (PA). Increases in PA activity were detected within 6 h of the addition of IgG and stimulation was dependent upon IgG concentration. Stimulation of PA activity was inhibited by cycloheximide, which indicates(More)
Interactions between T cells and epithelial cells of the thymus are essential for normal T cell development, and interactions between T cells and skin epidermal keratinocytes occur in the context of inflammatory skin diseases and cutaneous T cell malignancies. On the basis of observations that the T cell ALL cell line, HSB, bound to IFN-gamma activated(More)
Sllnunary Human thymic epithelial (TE) cells produce interleukin loe (Ibloe), I1:1~, and 11:6, cytokines that are important for thymocyte proliferation. The mRNAs for these cytokines are short-lived and are inducible by multiple stimuli. Thus, the steady-state levels for II.-1 and I1:6 mRNAs are critical in establishing the final cytokine protein levels. In(More)
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