Kay H. Singer

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The skin is an important site for immunological reactions (1-3). Cutaneous infiltration by T lymphocytes is characteristic of a number of disease states and T lymphocytes have been observed within the epidermal compartment in graft-vs.-host disease (4), lichen planus (5), and delayed-type hypersensitivity (6). In addition, a heterogeneous group of T(More)
Binding of anti-cell surface pemphigus autoantibodies to cultured human epidermal cells stimulates synthesis and secretion of plasminogen activator (PA). Increases in PA activity were detected within 6 h of the addition of IgG and stimulation was dependent upon IgG concentration. Stimulation of PA activity was inhibited by cycloheximide, which indicates(More)
Sllnunary Human thymic epithelial (TE) cells produce interleukin loe (Ibloe), I1:1~, and 11:6, cytokines that are important for thymocyte proliferation. The mRNAs for these cytokines are short-lived and are inducible by multiple stimuli. Thus, the steady-state levels for II.-1 and I1:6 mRNAs are critical in establishing the final cytokine protein levels. In(More)
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