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Intracellular Time Course, Pharmacokinetics, and Biodistribution of Isoniazid and Rifabutin following Pulmonary Delivery of Inhalable Microparticles to Mice
TLDR
It was concluded that inhaled microparticles can reduce dose frequency and improve the pharmacologic index of the drug combination.
Auditory Neuropathy/Dys-synchrony In School-aged Hearing-impaired Children: A South Indian Perspective
TLDR
The results indicate that auditory dyssynchrony is not an extremely rare disorder and although only a small portion of the population of children with hearing loss is affected, it is undoubtedly important to detect this disorder so that individualized treatment plans can be devised.
Partial biodistribution and pharmacokinetics of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to rhesus macaques.
TLDR
The results suggest that human patients would benefit through improvement in biodistribution following DPI, and flip-flop serum pharmacokinetics was observed, and nonlinearity in some pharmacokinetic parameters at logarithmic dose increments was indicated.
The effect of acute sleep deprivation on temporal processing and frequency resolution in normal healthy adults
TLDR
The mean gap detection test values were elevated in sleep deprivation conditions as compared to the baseline condition and the temporal modulation transfer function scores were increased in the sleep deprivation condition when compared tothe baseline condition.
Phospholipid Capped Mesoporous Nanoparticles for Targeted High Intensity Focused Ultrasound Ablation
TLDR
The synthesis of 100 nm nanoparticle ultrasound agents based on phospholipid-coated, mesoporous, hydrophobically functionalized silica nanoparticles that can internalize into cancer cells and remain acoustically active are reported.
Vestibular evoked myogenic potential in noise-induced hearing loss.
TLDR
It can be concluded that the possibility of vestibular dysfunction, specially the saccular pathway, is high in individuals with NIHL and VEMP, a non-invasive and user friendly procedure, can be employed in these individuals to assess sacculo-collic reflex.
Vestibular Evoked Myogenic Potential as a Tool to Identify Vestibular Involvement in Auditory Neuropathy
TLDR
Evidence is provided for involvement of the vestibular branch of the VIIIth cranial nerve in a high percentage of the auditory neuropathy population; hence, it is suggested that there is need for Vestibular assessment in cases of auditory Neuropathy that would help to better understand the disorder.
Preparation and in vitro characterization of Valsartan solid dispersions using skimmed milk powder as carrier.
Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. Consequences of poor aqueous solubility would lead to failure in formulation
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