Kaushik Puranam

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Apoptosis has been involved in a number of pathological conditions including coronary artery disease (CAD). Caspases (CASP) are important regulators and executioners in both extrinsic and intrinsic apoptotic pathways. The aim of the present study is to examine the role of Caspase 8 and 3 polymorphisms in the pathogenesis of CAD. CAD patients (n=300) and(More)
Breast cancer is the most common form of cancer worldwide. It is a potential life-threatening malignancy in women. The incidence of breast cancer is rising in developing countries such as, India. Most breast malignancies arise from epithelial elements and are categorized as carcinomas. Breast carcinomas are a diverse group of lesions that differ in(More)
Medicinal herbs are moving from fringe to mainstream use with a greater number of people seeking remedies.Forskolin, is a diterpene, the main active ingredient in the ayurvedic herb Coleus forskohliihas been used in India since prehistoric times in ayurvedic traditional medicine.Coleus forskohliiis a perennial aromatic herb found in subtropical regions of(More)
BACKGROUND Extracellular matrix degradation by matrix metalloproteinases (MMPs) is an important mechanism involved in tumor invasion and metastasis. Genetic variations of MMPs have shown association with multiple cancers. The present study is focused to elucidate the association of MMP-1, 3 and 9 genetic variants with respect to epidemiological and(More)
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