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Selective inhibitors of nuclear export (SINE)– a novel class of anti-cancer agents
Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in carcinogenesis. The nuclear export of proteins depends on the activity of transport proteins, exportins.Expand
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Colonic epithelial cell diversity in health and inflammatory bowel disease
The colonic epithelium facilitates host–microorganism interactions to control mucosal immunity, coordinate nutrient recycling and form a mucus barrier. Breakdown of the epithelial barrier underpinsExpand
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Selective inhibitors of nuclear export (SINE) in hematological malignancies
Regulated nucleo-cytoplasmic transport plays a major role in maintaining cellular homeostasis. CRM1 (chromosome region maintenance 1 or exportin 1 or XPO 1) is responsible for the nucleo-cytoplasmicExpand
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Suppression of p21Rac Signaling and Increased Innate Immunity Mediate Remission in Crohn’s Disease
Overactivation of p21Rac1 is a rate-limiting step for innate immune function in Crohn’s disease and prevents remission. Crohn’s Disease on the Rac Crohn’s disease is a type of inflammatory bowelExpand
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Evidence for a Minimal Eukaryotic Phosphoproteome?
Background Reversible phosphorylation catalysed by kinases is probably the most important regulatory mechanism in eukaryotes. Methodology/Principal Findings We studied the in vitro phosphorylation ofExpand
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CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte.
CD5(+) B lymphocytes have distinct functional properties compared with B lymphocytes that lack CD5. However, it remains unclear if and how the CD5 molecule modulates B lymphocyte biology andExpand
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Modulation of Src Activity by Low Molecular Weight Protein Tyrosine Phosphatase During Osteoblast Differentiation
Background: Src kinase plays a critical role in bone metabolism, particularly in osteoclasts. However, the ability of Src kinase to modulate the activity of other bone cells is less well understood.Expand
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Nano-Curcumin Inhibits Proliferation of Esophageal Adenocarcinoma Cells and Enhances the T Cell Mediated Immune Response
In Western countries the incidence of the esophageal adenocarcinoma (EAC) has risen at a more rapid rate than that of any other malignancy. Despite intensive therapies this cancer is associated withExpand
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Backwater control on riffle pool hydraulics, fish habitat quality, and sediment transport regime in gravel-bed rivers
Summary The importance of channel non-uniformity to natural hydrogeomorphic and ecological processes in gravel-bed rivers is becoming increasingly known, but its use in channel rehabilitation lagsExpand
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Protein phosphorylation and kinome profiling reveal altered regulation of multiple signaling pathways in B lymphocytes from patients with systemic lupus erythematosus.
OBJECTIVE The cause of B lymphocyte hyperactivity and autoantibody production in systemic lupus erythematosus (SLE) remains unclear. Previously, we identified abnormalities in the level andExpand
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