Kaushal Desai

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Using the North American Rheumatoid Arthritis Consortium (NARAC) candidate gene and genome-wide single-nucleotide polymorphism (SNP) data sets, we applied regression methods and tree-based random forests to identify genetic associations with rheumatoid arthritis (RA) and to predict RA disease status. Several genes were consistently identified as weakly(More)
Drug-induced neutropenia can be fatal when severe and therefore requires an improved understanding of its mechanism(s) of toxicity. Systems biology provides an opportunity to understand adverse events after drug administration using analysis of biomolecular networks. In this study, a human protein interaction network was analyzed to identify proteins that(More)
Systems toxicology, a branch of toxicology that studies drug effects at the level of biological systems, offers exciting opportunities to discover toxicity-related sub-networks using high-throughput technologies. This paper takes a computational approach to systems toxicology and investigates the use of automated signalling path detection for discovery of(More)
Numerous attempts have been made to increase the efficiency of clinical studies, but the productivity of clinical development remains low. This article describes an organization’s journey to enhance clinical program design, with a focus on decision-making so the right questions are asked and answered to support key decisions during development. AstraZeneca(More)
Optimal Caching of Large Multi-Dimensional Datasets Dinesh Obalappa Oleh J. Tretiak, Ph.D. We propose a novel organization for multi-dimensional data based on the concept of macro-voxels. This organization improves computer performance by enhancing spatial and temporal locality. Caching of macro-voxels not only reduces the required storage space but also(More)
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