Kaushal Desai

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Three empirical studies on characteristics of social classification are reported in this paper. The first study compared social tags with controlled vocabularies and title-based automatic indexing and found little overlaps among the three indexing methods. The second study investigated how well tags could be categorized to improve effectiveness of searching(More)
Using the North American Rheumatoid Arthritis Consortium (NARAC) candidate gene and genome-wide single-nucleotide polymorphism (SNP) data sets, we applied regression methods and tree-based random forests to identify genetic associations with rheumatoid arthritis (RA) and to predict RA disease status. Several genes were consistently identified as weakly(More)
Systems toxicology, a branch of toxicology that studies drug effects at the level of biological systems, offers exciting opportunities to discover toxicity-related sub-networks using high-throughput technologies. This paper takes a computational approach to systems toxicology and investigates the use of automated signalling path detection for discovery of(More)
Using the North American Rheumatoid Arthritis Consortium (NARAC) candidate gene and genome-wide single-nucleotide polymorphism (SNP) data sets, we applied regression methods and tree-based random forests to identify genetic associations with rheumatoid arthritis (RA) and to predict RA disease status. Several genes were consistently identified as weakly(More)
  • Kaushal Desai, Ian Fisher, Emma Witch, Laszlo Vasko, Christopher Miller, Martin Simán
  • 2014
Numerous attempts have been made to increase the efficiency of clinical studies, but the productivity of clinical development remains low. This article describes an organization's journey to enhance clinical program design, with a focus on decision-making so the right questions are asked and answered to support key decisions during development. AstraZeneca(More)
Drug-induced neutropenia can be fatal when severe and therefore requires an improved understanding of its mechanism(s) of toxicity. Systems biology provides an opportunity to understand adverse events after drug administration using analysis of biomolecular networks. In this study, a human protein interaction network was analyzed to identify proteins that(More)
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