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T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid organs. Here we show that pMHC contact modulates the expression of CD5 by naive CD4 T cells in a process that requires the continued expression of p56(lck). Reduced CD5(More)
The coordinated movement of the eyes and hands under visual guidance is an essential part of goal-directed behavior. Several cortical areas known to be involved in this process exchange projections with the dorsal aspect of the thalamic pulvinar nucleus, suggesting that this structure may play a central role in visuomotor behavior. Here, we used reversible(More)
The monoclonal antibody bevacizumab, targeted against the angiogenesis factor VEGF has clinical activity against several common cancers. In metastatic breast cancer it improves response rate and time to progression in combination with paclitaxel/docetaxel compared with paclitaxel/docetaxel alone; the drug is currently being investigated in other combination(More)
A vertex-magic total labeling (VMTL) of a graph is an assignment of the consecutive integers 1,2,3… to the vertices and edges of the graph, so that the sum of a vertex label and all labels on its incident edges is a constant not dependent on the choice of vertex. We show that the graph consisting of m disjoint copies of the complete graph with n vertices(More)
Most individuals diagnosed with hereditary hemochromatosis have mutations in both copies of the HFE gene, with such mutations being common in populations of north European origin. The number of individuals currently diagnosed and treated for hemochromatosis is small relative to the number carrying two HFE mutations. Studies searching for undiagnosed(More)
  • Mark Fillbrandt, Bigg Dogg, +37 authors Harold Ross
  • 2009
The mission of the NWROC is to contribute, within the framework of the Minnesota Agricultural Experiment Station (MAES) and the College of Food, Agricultural, and Natural Resource Sciences to the acquisition, interpretation and dissemination of research results to the people of Minnesota, with application to the knowledge base of the United States and(More)
One-hundred-twenty consecutive adult patients aged 15-69 years (median 40) with acute myeloid leukemia (AML) excluding t(15;17) received induction therapy comprising idarubicin, high-dose cytarabine and etoposide. Planned post-induction treatment included two courses of moderate-intensity consolidation therapy followed by stem cell transplantation. 11(More)
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