Katy M Unger

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Nine sedentary men 21 to 35 yr of age took part in a physical conditioning program involving regular aerobic exercise over a period of 6 to 8 wk. There was significant improvement in indexes of cardiorespiratory fitness. Ventilatory and mouth occlusion pressure responses to CO2 at rest and during threadmill exercise was measured before and after training.(More)
Flow cytometry allows rapid and accurate analysis of the deoxyribonucleic acid (DNA) content of a large number of cells. In solid tumors, the presence of aneuploidy has been shown to correlate wall with the presence of neoplastic cells. Both cytologic examination and DNA analysis by flow cytometry were performed on pleural effusions from 33 patients.(More)
BACKGROUND/AIMS Several recent studies revealed an accumulation of ceramide in bronchial, tracheal and intestinal epithelial cells of mice and patients with cystic fibrosis (CF). Normalization of ceramide concentrations in lungs of CF mice employing the functional acid sphingomyelinase inhibitor amitriptyline also normalized mucociliary clearance, chronic(More)
Among 27 patients with moderate-to-severe chronic obstructive lung disease, 22 had anatomic intrapulmonary shunting greater than that seen in normal subjects. The shunted blood passed through enlarged pulmonary vessels, as demonstrated with particles 10-90 microns in diameter. The shunt magnitude was correlated with the decrement in lung diffusing capacity.(More)
A malignant fibrous histiocytoma (MFH) arising in the lungs of a 51-year-old man was studied by light and electron microscopy. Features observed were identical to those of MFHs which occur in the skin and subcutaneous tissue and less commonly in other deep locations. By light microscopy, a storiform pattern with admixture of fibroblasts and histiocytes, as(More)
Patients with unresectable, chemo-refractory colorectal cancer liver metastases (CRCLM) have limited local treatment options. We report our institutional experience on the efficacy of resin-based yttrium-90 (90Y) radioembolization for the treatment of CRCLM and our findings on associated circulating cell-free DNA (ccfDNA) studies. A total of 58 patients(More)
Thoracic computed tomography (CT) was performed on 19 ICU patients to define chest abnormalities not clearly seen on conventional portable chest radiographs. In five (26%) of these cases, the CT demonstrated new findings that substantially altered the patient's course including malpositioned thoracostomy tubes, loculated pleural fluid, unsuspected(More)
Because the postulated mechanism of high altitude pulmonary edema is inhomogeneous vaconstriction and hyperperfusion of unconstricted vessels, pulmonary blood flow through vessels larger than 10 micron was determined at baseline and during acute hypoxia sufficient to reduce arterial oxygen saturation to 65%. Women demonstrated a uniform response of(More)