• Publications
  • Influence
Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway
TLDR
It is found that Cdc42, in addition to binding and activating the PAK‐like kinases Ste20 and Cla4, binds to the Ste11–Ste50 complex to bring activated Ste20/Cla4 to their substrate Ste11, then to Pbs2, to act as adaptor proteins that control the flow of the osmostress signal.
Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway
TLDR
It is shown that the mucin‐like transmembrane proteins Hkr1 and Msb2 are the potential osmosensors for the SHO1 branch of the HOG pathway, and that these proteins are the most upstream elements known so far in the SHo1 branch.
Glycosylation defects activate filamentous growth Kss1 MAPK and inhibit osmoregulatory Hog1 MAPK
TLDR
The reciprocal inhibitory loop between Kss1 and Hog1 allows only one or the other of these MAPKs to be stably activated under various stress conditions.
Osmosensing and scaffolding functions of the oligomeric four-transmembrane domain osmosensor Sho1
TLDR
It is demonstrated that the four-transmembrane (TM) domain protein Sho1 is an osmosensor in the HKR1 sub-branch of the HOG pathway, which coordinates adaptation to high osmolarity conditions.
Yeast Osmosensors Hkr1 and Msb2 Activate the Hog1 MAPK Cascade by Different Mechanisms
TLDR
A unique mechanism by which only one of these “redundant” pathways integrates osmotic stress signals withregulation of the actin cytoskeleton is revealed, which may enable differential regulation of these two proteins and provide a mechanism through Msb2 to connect regulation of the cytos skeleton with the response to osmatic stress.
Mutation of TRS130, which encodes a component of the TRAPP II complex, activates transcription of OCH1 in Saccharomyces cerevisiae
TLDR
The results suggest that the blocking of vesicle transport by a loss of the Trs130p function causes some defect in the cell wall mannoproteins, which leads to the elevated expression of OCH1 through the Skn7p function, to compensate for the defect.
Osmostress enhances activating phosphorylation of Hog1 MAP kinase by mono‐phosphorylated Pbs2 MAP2K
TLDR
It is reported that theMAP3K Ste11 phosphorylates only one activating phosphorylation site in Pbs2, whereas the MAP3Ks Ssk2/Ssk22 can phosphorylate both Ser‐514 and Thr‐518 under optimal osmostress conditions.
Scaffold Protein Ahk1, Which Associates with Hkr1, Sho1, Ste11, and Pbs2, Inhibits Cross Talk Signaling from the Hkr1 Osmosensor to the Kss1 Mitogen-Activated Protein Kinase
TLDR
Ahk1 is a scaffold protein in the HKR1 subbranch and prevents incorrect signal flow from Hkr1 to Kss1, which is a large, highly glycosylated, single-path transmembrane protein that is a putative osmosensor in one of the Hog1 upstream pathways termed the H KR1Subbranch.
Regulation of mating type switching by the mating type genes and RME1 in Ogataea polymorpha
TLDR
Investigation of the roles of transcription factors involved in yeast sexual development found that co-presence of mating type a1 and α2 genes was sufficient to prevent mating type switching, suggesting that ploidy information resides solely in the mating type locus.
...
1
2
...