Katsuyoshi Okayama

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Stiff-man syndrome (SMS) is characterized by fluctuating muscular rigidity and spasm. Recently, antibodies against glutamic acid decarboxylase (GAD), the enzyme catalyzing the synthesis of y-amino butyric acid (GABA), have been detected in SMS patients. An autoimmune mechanism against GAD was thus proposed for the suppression of GABAergic inhibitory(More)
It has been well established that acquired lesions of the corpus callosum such as surgical section bring about disturbances of interhemispheric transfer of visual information. In contrast, patients with callosal agenesis do not display these specific deficits. The mechanisms of this compensation have been postulated as follows; (1) bilateral development of(More)
Autoradiography (ARG) has been used for quantitative analysis of the cerebral blood flow using <sup>123</sup>I-IMP, and the regional cerebral blood flow (rCBF) can be assessed more accurately with scatter and attenuation correction. Currently, the filtered back projection (FBP) method is generally used for image reconstruction. However, we anticipate(More)
The patient was a 35-year-old man with confusional state and headache. Analysis of cerebrospinal fluid (CSF) showed 1,383/mm3 cell count, the protein level of 300mg/dl and glucose level of 42 mg/dl. Cryptococcus neoformans was disclosed by India ink preparation. The cryptococcal antigen test was positive at 1:125 by latex agglutination. The diagnosis of(More)
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