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AIMS The receptor for B-cell-activating factor belonging to the tumour necrosis factor family (BAFF-R) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) have been established as binding molecules to BAFF. The aim of this study was to determine the pathological diagnostic roles and clinical significance of these(More)
Sporadic Parkinson's disease (sPD) is a common neurodegenerative disorder, characterized by selective degeneration of dopaminergic neurons in the substantia nigra. Although the pathogenesis of the disease remains undetermined, phosphorylation of alpha-synuclein and its oligomer formation seem to play a key role. However, the protein kinase(s) involved in(More)
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity disease of the lung caused by the inhalation of Aspergillus species (1). ABPA shows blood and pulmonary eosinophilia, increased serum immunoglobulin E (IgE) levels, episodic wheezing, and occasional expectoration of brown plugs. Eosinophil can damage tissues by the release of toxic granule(More)
BACKGROUND AND PURPOSE Inflammatory processes are involved in the pathogenesis of atherosclerosis. Inflammation has been known as a risk factor for coronary heart disease, whereas inflammation as a risk for cerebrovascular disease is less well established. Whether inflammatory processes, excluded from their involvement in large-vessel disease, are(More)
We report a first case of HIV-associated lymphoma (HAL) presenting with acute kidney injury (AKI) and inflammatory immune reconstitution syndrome (IRIS). A 39-year-old male, treated with nonsteroidal anti-inflammatory drugs (NSAIDs) for one month prior to admission, developed AKI, left testicular tumor, and recurrent swelling of the right parotid gland. A(More)
 Tracheopathia osteochondroplastica (TO) is an unusual condition characterized by cartilaginous or bony submucosal nodules in the tracheobronchial tree. Bone morphogenetic protein-2 (BMP-2) and transforming growth factor beta-1 (TGF-β1) are potent inducers for new bone formation. We studied the precise localization of BMP-2 and TGF-β1 in two autopsied cases(More)
To clarify the clinical outcome of peripheral T-cell lymphomas (PTCLs), we conducted a retrospective review comparing the outcomes of patients with PTCL (nodal peripheral T-cell lymphoma, unspecified, n=34 ; angioimmunoblastic T-cell lymphoma, n=12) to those with diffuse large B-cell lymphoma (DLBCL, n=48). All patients received CHOP-based chemotherapy(More)
Dear Editor, Rituximab is an effective and safe monoclonal antibody in the treatment of CD20+ malignant lymphoma [1]. In patients with massive pleural effusions or ascites associated with lymphoma, it remains unclear whether rituximab should be administered not only by intravenous infusion but also via the intraperitoneal route [2–4]. We studied the(More)
Recent studies have supported the hypothesis that gastrointestinal stromal tumors (GIST) originate in a stem cell that differentiates toward an interstitial cell of Cajal (ICC) phenotype (1–3). The ICCs, which have been shown to form a network at the outer edge of the submucosa, in the circular muscle layer, and around the myenteric plexus, have a(More)
Microalbuminuria (MA) is known as a marker for generalized vascular dysfunction. It occurs most commonly in the setting of diabetes and hypertension; however, its association with cerebral small vessel disease (SVD) in community-based elderly remains to be clarified. In this cross-sectional analysis, we evaluated the association between MA and cerebral SVD(More)