Katsuhiro Mabe

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BACKGROUND In Japan, treatment guidelines are lacking for patients with upper gastrointestinal symptoms. We aimed to compare the efficacy of different drugs for the treatment of uninvestigated upper gastrointestinal symptoms. METHODS This was a randomized, open-label, parallel-group multicenter study. Helicobacter pylori-negative, endoscopically(More)
BACKGROUND Magnifying endoscopy with narrow-band imaging (ME-NBI) and a simple and systematic classification system based on microvascular and microsurface patterns, the "VS" classification system (VSCS), have been shown to be useful for the diagnosis of early gastric cancer. The aim of this study was to clarify whether an educational lecture about the VSCS(More)
In Japan, efforts have been directed toward improving the detection of early gastric cancer by double contrast radiography and endoscopy, since early cancer has a good prognosis, resulting in Japan having the world's best diagnostic system for early gastric cancer. The 5-year survival rate of gastric cancer patients in Japan is much higher than in Western(More)
BACKGROUND Proton pump inhibitors (PPIs) are affected by cytochrome P450 2C19 (CYP2C19) polymorphisms. This study compared the effect of two PPIs on early symptom relief in Japanese patients with reflux esophagitis, classified by the CYP2C19 phenotype. METHODS Patients with reflux esophagitis were randomised to treatment with omeprazole 20 mg or(More)
Helicobacter pylori is a key factor in the development of gastric cancer; indeed, clearance of H. pylori helps prevent gastric cancer. However, the relationship between gastric cancer and the abundance and diversity of H. pylori genotypes in the stomach remains unknown. Here, we present, for the first time, a quantitative analysis of H. pylori genotypes in(More)
AIM To clarify the current state of practice for colonic diverticular bleeding (CDB) in Japan. METHODS We conducted multicenter questionnaire surveys of the practice for CDB including clinical settings (8 questions), diagnoses (8 questions), treatments (7 questions), and outcomes (4 questions) in 37 hospitals across Japan. The answers were compared(More)
BACKGROUND For endoscopic interventions, heparin bridging therapy is recommended in patients who are at high risk from interruption of antithrombotic therapy. Although heparin bridging has been reported to be effective in preventing thrombosis, several reports have raised concerns about increased risk of bleeding. The aim of this study was to clarify(More)
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