Katsuhiko Ohori

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BACKGROUND Ischemic preconditioning accelerates suppression of gap junction (GJ) permeability during myocardial ischemia, and GJ blockers reduce infarct size. We hypothesized that the mitochondrial ATP-sensitive K+ (mitoKATP) channel is one of the mechanisms regulating GJ permeability through the mitogen-activated protein kinase ERK, leading to(More)
of rheumatic mitral stenosis 20 years previously. The patient was readmitted for treatment of idiopathic fever. On admission , slight fever (37.2°C), blood pressure of 121/96 mmHg, and a pulse rate of 68 beats/min were recorded. Auscultation of the heart produced a metallic click sound without significant murmur. On blood tests, white blood cell count and(More)
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