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OBJECTIVES Few studies have investigated the incidence of eating disorders (EDs). Important questions about changes in the incidence of diagnosed disorders in recent years, disorder and gender-specific onset and case detection remain unanswered. Understanding changes in incidence is important for public health, clinical practice and service provision. The(More)
OBJECTIVES This study aimed to estimate rates of cancer or opportunistic infection in patients with psoriatic arthritis (PsA) compared with patients without PsA. METHODS Using the Clinical Practice Research Datalink, we conducted a cohort study of patients with a PsA diagnosis and patients without such diagnosis, matched on age, sex, general practice, and(More)
BACKGROUND Type II diabetes increases liver cancer risk but the risk may be mitigated by anti-diabetic medications. However, choice of medications is correlated with diabetes duration and severity, leading to confounding by indication. METHODS To address this association, we conducted a nested case-control study among persons with type II diabetes in the(More)
BACKGROUND Bone is a frequent site for metastases among women with breast cancer. We conducted a study using the General Practice Research Database (GPRD), with linkage to the National Cancer Registry (NCR) and Hospital Episode Statistics (HES), to estimate the incidence of bone metastases in women with breast cancer in the United Kingdom. METHODS We(More)
OBJECTIVE To investigate the relation of various estrogen-containing hormone therapies to the risk of breast cancer, emphasizing the use of the combination of estrogen and testosterone. METHODS Using information from a large U.S.-based claims database, we conducted a case-control study in women aged 50 to 64 years who had a first-time diagnosis of breast(More)
BACKGROUND Concern has been raised that the risk of venous thromboembolism (VTE) in users of the ORTHO EVRA patch is higher compared to users of oral contraceptives (OCs). STUDY DESIGN We identified idiopathic cases of VTE and controls, matched on age and index date, from among women in the United States PharMetrics/IMS and MarketScan databases who were(More)
BACKGROUND This study aimed to estimate the prevalence of chronic kidney disease (CKD) in the UK in 2010 and to assess prevalence, comorbidities and comedications associated with the disease over time, following inclusion of CKD in the Quality and Outcomes Framework (QOF). METHODS This was a retrospective, longitudinal study assessing individuals with(More)
The interaction of the time between blinks, or the interblink interval (IBI), and tear film breakup time (TFBUT) helps to regulate the integrity of the ocular surface. A protected surface exists when the TFBUT matches or exceeds the IBI. In contrast, an unprotected surface exists when TFBUT is less than the IBI. This is clinically relevant because repeated(More)
STUDY OBJECTIVE To estimate the effectiveness of influenza vaccination in people in the United Kingdom at low risk for influenza during an 11-year period from July 1996-June 2007. DESIGN Case-control study. DATA SOURCE United Kingdom General Practice Research Database. SUBJECTS A total of 4985 patients (aged < 80 yrs) who were considered to be at low(More)
STUDY OBJECTIVE To estimate the rate of suicide in patients taking montelukast. DESIGN Population-based cohort study. DATA SOURCE United Kingdom General Practice Research Database. PATIENTS A total of 23,500 patients who had received at least one prescription for montelukast in the cumulative data from February 1998-March 2007. MEASUREMENTS AND MAIN(More)