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PI3K/p110α inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization: potential implications for drug-eluting stent design.
BACKGROUND Impaired re-endothelialization and stent thrombosis are a safety concern associated with drug-eluting stents (DES). PI3K/p110α controls cellular wound healing pathways, therebyExpand
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Chemical activation and changes in surface morphology of poly(ε-caprolactone) modulate VEGF responsiveness of human endothelial cells
The high degree of clinical routine in percutaneous transluminal coronary angioplasty (PTCA) with and without stenting has not changed the fact that a large number of coronary heart disease patientsExpand
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In vitro study of drug-eluting stent coatings based on poly(l-lactide) incorporating cyclosporine A – drug release, polymer degradation and mechanical integrity
In this study, absorbable polymer stent coatings for localized drug delivery based on poly(l-lactide) (PLLA) and cyclosporine A (CsA) were developed and tested in vitro. Metallic stents were coatedExpand
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In vivo 7.1 T magnetic resonance imaging to assess the lens geometry in rabbit eyes 3 years after lens‐refilling surgery
PURPOSE: To evaluate the utility of high‐resolution magnetic resonance imaging (MRI) in assessing the normal and refilled lens geometry in rabbits after lens‐refilling surgery. SETTING: University ofExpand
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In vitro study of dual drug-eluting stents with locally focused sirolimus and atorvastatin release
Within the context of novel stent designs we developed a dual drug-eluting stent (DDES) with an abluminally focussed release of the potent anti-proliferative drug sirolimus and a luminally focussedExpand
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Influence of sirolimus-loaded nanoparticles on physiological functions of native human polymorphonuclear neutrophils.
UNLABELLED Sirolimus (SRL) is an immunosuppressive agent of high clinical relevance that has been associated with serious side effects. Biodegradable, SRL-loaded poly(d,l-lactide) nanoparticlesExpand
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Response of umbilical cord mesenchymal stromal cells to varying titanium topographical signals.
A wide variety of titanium implant modifications have been developed to improve tissue- or cell-material interactions including bone bonding, implant failure, and contact osteogenesis. OsteogenesisExpand
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Biodegradable Polymers Influence the Effect of Atorvastatin on Human Coronary Artery Cells
Drug-eluting stents (DES) have reduced in-stent-restenosis drastically. Yet, the stent surface material directly interacts with cascades of biological processes leading to an activation of cellularExpand
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Cell-specific expression of uptake transporters--a potential approach for cardiovascular drug delivery devices.
Enhanced proliferation of human coronary artery smooth muscle cells (HCASMCs) and thereby formation of neointima is one of the factors contributing to failure of coronary stents. Even if the use ofExpand
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Antimicrobial Silver Multilayer Coating for Prevention of Bacterial Colonization of Orthopedic Implants
Due to increasing rates of periprosthetic joint infections (PJI), new approaches are needed to minimize the infection risk. The first goal of this study was to modify a well-established infectionExpand
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