Katrin Lunze

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A method for optimal continuous insulin therapy for diabetes patients has been sought since the early 1970s. Although technical and medical advances have been made, a fully automated artificial pancreas to replace the functions of the natural organ is still a research aim. This review compares recent control algorithms for type 1 diabetic patients which(More)
This paper introduces an improved physiological animal model with diabetic Göttingen minipigs, which focuses on the application of human therapy devices and metabolic system analysis. Based on measurement data-sets collected by metabolic test procedures, a new mathematical minipig model is developed. The model consists of 16 differential equations and(More)
While contactless vital sign monitoring technologies provide the great opportunity of fast and simple measurements, all these technologies have the unavoidable drawback that they suffer from strong motion artifacts. These motion artifacts may severely disrupt the signal of interest, which could lead to false peak detections and hence, result in false(More)
Development of an artificial pancreas which regulates blood glucose in a closed loop framework is the ultimate goal in the treatment of diabetes. Development of a model which captures the glucose-insulin dynamic is a mandatory step prior to the in vivo-test and validation of a feedback controller. Towards this end, the focus of this paper is on the(More)
Abstract: Despite continuous research effort, patients with type 1 diabetes mellitus (T1D) experience difficulties in daily adjustments of their blood glucose concentrations. New technological developments in the form of implanted intravenous infusion pumps and continuous blood glucose sensors might alleviate obstacles for the automatic adjustment of blood(More)
Diabetes mellitus is a widespread metabolic disease, which currently requires manual treatment. Until now, no commercial closed-loop insulin therapy system has been presented yet due to many control restrictions. To reduce safety risks for the patients, adequate control methods should be tested in animal trials, prior to clinical studies, which can be(More)
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