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We have recently mapped the genetic defect underlying pseudoxanthoma elasticum (PXE), an inherited disorder characterized by progressive calcification of elastic fibers in skin, eye, and cardiovascular system, to chromosome 16p 13.1. Here we report further data on the fine-mapping and genomic structure of this locus. Haplotype analysis of informative PXE(More)
While contactless vital sign monitoring technologies provide the great opportunity of fast and simple measurements, all these technologies have the unavoidable drawback that they suffer from strong motion artifacts. These motion artifacts may severely disrupt the signal of interest, which could lead to false peak detections and hence, result in false(More)
Development of an artificial pancreas which regulates blood glucose in a closed loop framework is the ultimate goal in the treatment of diabetes. Development of a model which captures the glucose-insulin dynamic is a mandatory step prior to the in vivo-test and validation of a feedback controller. Towards this end, the focus of this paper is on the(More)
— Diabetes mellitus is a widespread metabolic disease , which currently requires manual treatment. Until now, no commercial closed-loop insulin therapy system has been presented yet due to many control restrictions. To reduce safety risks for the patients, adequate control methods should be tested in animal trials, prior to clinical studies, which can be(More)
Despite continuous research effort, patients with type 1 diabetes mellitus (T1D) experience difficulties in daily adjustments of their blood glucose concentrations. New technological developments in the form of implanted intravenous infusion pumps and continuous blood glucose sensors might alleviate obstacles for the automatic adjustment of blood glucose(More)
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