Katrin C. Müllers

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We investigated the RESS process as a means of simultaneous micronization and cocrystallization of a model drug with poor aqueous solubility. 1:1 cocrystals of ibuprofen (IBU) and nicotinamide (NA) were produced with a pilot scale unit for RESS processing.IBU and NA were dissolved in scCO2 at 30 MPa and 50°C. After 24 h, the supercritical solution was(More)
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