Aurelio Ariza18
Isidro Ferrer9
Cristina Carrato6
Sarah Petry4
K Beyer4
18Aurelio Ariza
9Isidro Ferrer
6Cristina Carrato
4Sarah Petry
4K Beyer
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Previous test data on unreinforced masonry walls focused on the global response of the wall. A new dataset on six wall tests, which is publically available, allows linking global to local deformations of masonry walls, which can be useful for advancing performance-based design and assessment methods for unreinforced masonry buildings. This data paper(More)
SUMMARY This article presents a new mechanical model for the non-linear force–displacement response of unrein-forced masonry (URM) walls developing a flexural rocking mode including their displacement capacity. The model is based on the plane-section hypothesis and a constitutive law for the masonry with zero tensile strength and linear elastic behaviour in(More)
Keywords: Unreinforced masonry Drift capacity Boundary conditions Size effects Quasi-static cyclic tests Walls a b s t r a c t In codes the drift capacity of unreinforced masonry (URM) walls is often estimated as a function of the failure mode and the aspect ratio. The empirical relationships are based on results from quasi-static cyclic tests on single URM(More)
Lewy body diseases include Parkinson disease and dementia with Lewy bodies and are characterized by the widespread distribution of Lewy bodies in virtually every brain area. The main component of Lewy bodies is alpha-synuclein (AS). Accumulating evidence suggests that AS oligomerization and aggregation are strongly associated with the pathogenesis of Lewy(More)
Alternative splicing is an important mechanism to generate a large number of mRNAs, thus increasing proteome diversity and tissue specificity. Three transcript variants of alpha-synuclein, a neuronal protein mainly involved in synapses, have been described so far. Whereas alpha-synuclein 140 is the whole and main transcript, alpha-synuclein 112 and 126 are(More)
Alpha-synuclein, parkin, and synphilin-1 are proteins mainly involved in the pathogenesis of Lewy body (LB) diseases. mRNAs of all three undergo alternative splicing, so that the existence of various isoforms has been described. Since increasing evidence supports the importance of differential isoform-expression changes in disease development, we have(More)
MOTIVATION The untranslated regions (UTRs) of mRNA upstream (5'UTR) and downstream (3'UTR) of the open reading frame, as well as the mRNA precursor, carry important regulatory sequences. To reveal unidentified regulatory signals, we combine information from experiments with computational approaches. Depending on available knowledge, three different(More)
Synucleinopathies are characterized by the presence of different types of alpha-synuclein (AS)-positive inclusion in the brain. Thus, whereas Lewy bodies are the hallmark of Parkinson disease and dementia with Lewy bodies, glial and neuronal cytoplasmic inclusions are shown by multiple system atrophy. Because the main component of all these inclusions is(More)
Lewy body diseases are characterized by the presence of Lewy bodies, alpha-synuclein(AS)-positive inclusions in the brain. Since their main component is conformationally modified AS, aggregation of the latter is thought to be a key pathogenic event in these diseases. The analysis of inclusion body constituents gives additional information about pathways(More)
Alternative splicing gives rise to at least seven parkin and eight synphilin-1 isoforms. Since both parkin and synphilin-1 have been involved in Lewy body (LB) formation, we decided to explore whether their isoforms are differentially expressed in LB diseases. With this aim, we studied relative mRNA expression levels of parkin and synphilin-1 isoforms in(More)