Katrin Beyer

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α-Synuclein aggregation is thought to be a key event in the pathogenesis of synucleinopathies. Although different α-synuclein alterations and modifications have been proposed to be responsible for early aggregation steps, the mechanisms underlying these events remain unclarified. α-Synuclein is a small protein localized to synaptic terminals and its(More)
Dementia with Lewy bodies (DLB) is characterized by the widespread presence of Lewy bodies (LBs) in the brain. alpha-Synuclein, the main component of LBs, is expressed as two main isoforms (112 and 140), but little is known about their differential expression in the brain. We compared alpha-synuclein 112 and alpha-synuclein 140 expression levels in the(More)
Alpha-synuclein, parkin, and synphilin-1 are proteins mainly involved in the pathogenesis of Lewy body (LB) diseases. mRNAs of all three undergo alternative splicing, so that the existence of various isoforms has been described. Since increasing evidence supports the importance of differential isoform-expression changes in disease development, we have(More)
Cystatin C is an amyloidogenic protein that colocalizes with beta-amyloid (Abeta) within arteriolar walls in Alzheimer disease (AD) brains. Recently, a coding polymorphism in the cystatin C gene (CST3) has been claimed to confer risk for the development of late-onset AD. In the present work we have tested the frequencies of CST3-A and CST3-G alleles and(More)
In codes the drift capacity of unreinforced masonry (URM) walls is often estimated as a function of the failure mode and the aspect ratio. The empirical relationships are based on results from quasi-static cyclic tests on single URM walls, which were tested simulating either fixed-fixed or cantilever boundary conditions. In real structures, the stiffness(More)
Synucleinopathies are characterized by the presence of different types of alpha-synuclein (AS)-positive inclusion in the brain. Thus, whereas Lewy bodies are the hallmark of Parkinson disease and dementia with Lewy bodies, glial and neuronal cytoplasmic inclusions are shown by multiple system atrophy. Because the main component of all these inclusions is(More)
Alternative splicing is an important mechanism to generate a large number of mRNAs, thus increasing proteome diversity and tissue specificity. Three transcript variants of alpha-synuclein, a neuronal protein mainly involved in synapses, have been described so far. Whereas alpha-synuclein 140 is the whole and main transcript, alpha-synuclein 112 and 126 are(More)
Lewy body diseases include Parkinson disease and dementia with Lewy bodies and are characterized by the widespread distribution of Lewy bodies in virtually every brain area. The main component of Lewy bodies is alpha-synuclein (AS). Accumulating evidence suggests that AS oligomerization and aggregation are strongly associated with the pathogenesis of Lewy(More)
Damage to structural walls in the recent earthquakes in Chile (2010) and New Zealand (2011) demonstrated that modern reinforced concrete (RC) walls may not achieve the expected ductile response but could possibly be triggered by out-of-plane displacements of the wall. Following a review of the mechanisms that cause global out-of-plane buckling of RC walls,(More)
Unreinforced masonry (URM) walls comprise vertical piers and horizontal spandrels, which together form the lateral load resisting system. Whereas past research yielded significant advances in the understanding of the force–deformation characteristics of masonry piers, knowledge of the behaviour of masonry spandrels is lacking. This paper makes a(More)