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Alternative splicing is an important mechanism to generate a large number of mRNAs, thus increasing proteome diversity and tissue specificity. Three transcript variants of alpha-synuclein, a neuronal protein mainly involved in synapses, have been described so far. Whereas alpha-synuclein 140 is the whole and main transcript, alpha-synuclein 112 and 126 are(More)
Alpha-synuclein, parkin, and synphilin-1 are proteins mainly involved in the pathogenesis of Lewy body (LB) diseases. mRNAs of all three undergo alternative splicing, so that the existence of various isoforms has been described. Since increasing evidence supports the importance of differential isoform-expression changes in disease development, we have(More)
Keywords: Unreinforced masonry Drift capacity Boundary conditions Size effects Quasi-static cyclic tests Walls a b s t r a c t In codes the drift capacity of unreinforced masonry (URM) walls is often estimated as a function of the failure mode and the aspect ratio. The empirical relationships are based on results from quasi-static cyclic tests on single URM(More)
Previous test data on unreinforced masonry walls focused on the global response of the wall. A new dataset on six wall tests, which is publically available, allows linking global to local deformations of masonry walls, which can be useful for advancing performance-based design and assessment methods for unreinforced masonry buildings. This data paper(More)
PREPRINT This preprint is a PDF of a manuscript that has been accepted for publication in Earthquake Spectra. It is the final version that was uploaded and approved by the author(s). While the paper has been through the usual rigorous peer review process for the Journal, it has not been copyedited, nor have the figures and tables been modified for final(More)
In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: Keywords: Unreinforced brick masonry Spandrel elements Peak strength Residual strength(More)
Alpha-synuclein aggregation is thought to be a key event in the pathogenesis of synucleinopathies. Although different alpha-synuclein alterations and modifications have been proposed to be responsible for early aggregation steps, the mechanisms underlying these events remain unclarified. Alpha-synuclein is a small protein localized to synaptic terminals and(More)
Lewy body diseases include Parkinson disease and dementia with Lewy bodies and are characterized by the widespread distribution of Lewy bodies in virtually every brain area. The main component of Lewy bodies is alpha-synuclein (AS). Accumulating evidence suggests that AS oligomerization and aggregation are strongly associated with the pathogenesis of Lewy(More)
Behavioral dysfunction is a problem in patients with Alzheimer disease (AD), and is apparent in up to 67% of individuals. Such changes are a primary cause of individual institutionalization and often lead to their functional disability. As AD progresses, the worsening of behavioral dysfunction becomes increasingly evident and is linked with decreased(More)
Damage to structural walls in the recent earthquakes in Chile (2010) and New Zealand (2011) demonstrated that modern reinforced concrete (RC) walls may not achieve the expected ductile response but could possibly be triggered by out-of-plane displacements of the wall. Following a review of the mechanisms that cause global out-of-plane buckling of RC walls,(More)