Katrin Appel

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Primary mRNA transcripts in several systems are edited by single base substitutions, small deletions or insertions to yield functional messenger RNA species. Mitochondrial mRNAs in particular, including those from plants, seem to be the subject of extensive editing, unlike mRNAs encoded by chloroplast DNA, for which the prediction of amino-acid sequence(More)
p53 plays an essential role in cellular growth control. Some of its distinct biological functions are regulated by interaction with cellular proteins. We have previously (Wagner et al., 1994) shown that p53 binds to the regulatory subunit of protein kinase CK2. Using C-terminal protein fragments of p53 we now demonstrate that the region between amino acids(More)
Expression of the growth suppressor gene p53 in Schizosaccharomyces pombe causes growth arrest which can be suppressed by overexpression of a yeast gene termed tms1. The tms1 gene encodes a 37 KDa protein which binds to p53 in vitro and in vivo when p53 was expressed in fission yeast cells. By using antibodies against recombinant tms1 protein we analyzed(More)
Binding of p53 to cellular and viral proteins seems to be implicated in the regulation of its growth suppressor or oncogenic activity. Casein kinase II is among the proteins which tightly associate with p53 and which phosphorylate p53 at a C-terminal amino acid residue. In the present study we demonstrate that immunopurified full length p53 as well as a(More)
There is a controversial and ongoing debate on whether mental distress is moderated by an interaction between the insertion or deletion promoter polymorphism of the serotonin transporter gene (5HTTLPR) and life adversities. In particular, two metaanalyses published in 2009, which were based on a selection of 5 and 14 studies (from 34 observational studies(More)
In a screening program for antibiotics which were antagonized by cysteine, a strain, which was characterized as Ustilago sp., was found to produce a new quinone antibiotic, gunacin. The molecular weight M+ = 348.084 determined by mass spectroscopy, corresponds to a molecular formula of C17H16O8. Further spectroscopic data prove that gunacin is a new(More)
relative effect of each stimuli, showed a significant increased response of the vector containing the 3 allele compared with the 2 allele at every treatment (P < 0.01). We thus have shown by the functional magnetic resonance imaging that homozygotes for the 3 allele of the Int8 VNTR in DAT1 show disruption of normal reward related processes mediated by the(More)